Aims:We aim (i) to redesign sepsis's clinical pathway and fit the organizational requirements of a novel machine-learning algorithm incorporating a novel biomarker test and (ii) to assess adoption drivers of the new combined technology.Background: There is an urgent need to achieve sepsis' early detection and diagnostic excellence.Methods: A qualitative study based on semi-structured interviews conducted at the target site and across other Italian hospitals. A content analysis was undertaken, emergent themes were selected and categorized, and interviews were conducted until saturation was reached.Results: Sixteen nurses (10 at the target site and six across other hospitals) and nine non-nursing professionals (seven at the target site and two across other hospitals) were interviewed. An organizational redesign was identified as the primary adoption driver. Even though nurses perceived workload increase related to the machine-learning component, technology acceptability was relatively high, as the standardization of tasks was perceived as crucial to improving professional satisfaction.Conclusions: A novel business-oriented solution based on machine learning requires interprofessional integration, new professional roles, infrastructure improvement, and data integration to be effectively implemented.Implications for Nursing Management: Lessons learned from this study suggest the need to involve nurses in the early stages of the design of new machine-learning technologies and the importance of training nurses on sepsis management through the support of disruptive technological innovation.[Correction added on 15 December 2022, after first online publication: The third author's surname has been corrected from 'Benedectis' to 'Benedictis' in this version.]