Although the correlation between traffic variables and weather appears to be intuitive, quantifying the effects that weather, especially rain, has on driver response in travel speeds and traffic demands is needed to evaluate practical aspects of traffic operations. Previous studies have researched driver responses to inclement weather on freeways located in northern regions of the United States and Canada. However, driver familiarity with local weather conditions is a factor that should be considered in determining inclement weather effects on traffic variables. The focus of this research was to examine driver response to rain precipitation on freeways located in the southeastern regions of the United States to determine whether results from previous studies were general indicators or location specific in nature. To study the impacts of rain precipitation on hourly mean speeds and traffic volumes, hourly weather data and traffic sensor data were collected for two freeway segments in Jacksonville, Florida. The study investigated conditions such as wet versus dry (rain or no rain) and dry versus rain intensity (no rain or light, moderate, or heavy rain) for each segment. The results indicated that mean travel speeds decreased during rainfall events and speed reductions increased with increasing rain intensity. Reductions found for light rainfall events were within the range of previous studies; however, speed reductions during moderate to heavy rains varied widely. The results also indicated that the hour of the day was a factor in the degree of motorists’ speed reduction. Traffic volumes also declined during rainy conditions, with significant reductions during peak hours.