Aims: This qualitative literature review aims to critically assess and analyse published literature to determine drivers influencing over-prescribing by general practitioners (GPs) in primary care, exploring their views and opinions, and also to determine how antibiotic prescribing can be improved and unnecessary prescribing reduced, thus reducing the threat to public health from antibiotic resistance. It is intended to develop new thinking in this area and add to existing knowledge concerning GPs’ antibiotic prescribing behaviour. Methods: Thematic analysis following Braun and Clarke’s 2006 framework was used to analyse 17 qualitative studies chosen from EBSCOhost databases, focusing on GPs’ views of antibiotic prescribing in primary care, with specific search strategies and inclusion criteria to ensure study quality and trustworthiness. Results: Three main themes and nine sub-themes were generated from the studies. The first main theme discussed GP factors related to over-prescribing, the main drivers being GP attitudes and feelings and anxiety/fear concerning prescribing. The second theme highlighted external factors, with pressures from time and financial issues as the main drivers within this theme. The final theme marked patient pressure, demand and expectation with lack of patient education as the major drivers affecting GP over-prescribing. Conclusion: The findings of this research show GPs’ antibiotic prescribing in primary care is complex, being influenced by many internal and external factors. A multifaceted approach to interventions targeting the drivers identified could significantly reduce the level of antibiotic prescribing thus minimising the impact of antibiotic resistance and promoting a more efficient working environment for GPs and patients alike.

Introduction: The increasing threat of antibiotic resistance (ABR) is, inevitably, the consequence of antibiotic use and is largely influenced by the knowledge and perceptions of people and their socioeconomic environment. Aims: The aims of this study were to ascertain the comprehensive knowledge, perceptions, and attitudes of people from varying socioeconomic regions towards antibiotic use; identify the misperceptions and malpractices; and inform health policy and practice. Method: EBSCO host databases, PubMed, and Google Scholar were searched to obtain relevant primary research papers within the years 2010–2018. Search phrases included the following: ‘antibiotics use’, ‘community perceptions’, ‘public opinion, knowledge, behaviour, practices, perceptions’. Initially, selected papers were screened using the Preview, Question, Read, Summarize (PQRS) model. Results: Review of the 20 articles selected was based on six identified themes. It was found that insufficient knowledge and awareness of antibiotics use; self-medication and the use of leftover antibiotics; treating viral diseases with antibiotics or used as painkillers; expecting antibiotic prescription as a culmination of consultation; and the credibility of information obtained are issues that cut across different countries. Conclusion: Evidence from this review suggests that misconceptions of antibiotic use are similar in different countries. Therefore, the need for the development and implementation of transferable policies as well as educating the public is necessary for the fight against ABR.