During the COVID-19 pandemic, resources informing parents on how they should discuss the topic with their children surfaced. However, little is known about the questions that children ask about COVID-19 (and the pandemic in general) and how parents respond to those questions. In this exploratory mixed-method study, we recruited 349 predominantly White U.S. parents with children between the ages of 3 and 12 to examine children’s questions and parents’ answers about the COVID-19 pandemic. We found children primarily asked about lifestyle changes that occurred as a result of the pandemic. Parents answered questions by emphasizing that the purpose of different preventative measures were designed to protect the child, the family or society at large. Our results suggest that providing parents information about how to discuss lifestyle changes (rather than just the virus) with their children might help prepare parents to provide better answers to their children questions.