Tebipenem pivoxil hydrobromide is a novel orally bioavailable prodrug of tebipenem, a carbapenem antimicrobial, that binds to penicillin‐binding proteins, inhibiting the synthesis of the bacterial cell wall. This results in weakening of peptidoglycan, leading to lysis of bacterial cells. Tebipenem displays a broad spectrum of activity against anaerobic, gram‐positive, and gram‐negative pathogens, including extended‐spectrum β‐lactamase producing Enterobacterales. In a large phase 3 clinical trial (ADAPT‐PO), oral tebipenem pivoxil hydrobromide 600 mg every 8 h was shown to be non‐inferior to intravenous ertapenem 1 g every 24 h. Overall response at test of cure was 58.8% [264/449] in the tebipenem pivoxil hydrobromide group compared to 61.6% [258/419] in the ertapenem group for the treatment of complicated urinary tract infections, including acute pyelonephritis. At the test of cure, clinical cure rates were 93.1% and 93.6% and microbiological eradication was 59.5% and 63.5% with tebipenem pivoxil hydrobromide and ertapenem, respectively. The most common adverse reactions associated with tebipenem pivoxil hydrobromide are diarrhea, headache, and nausea. As with other carbapenems, tebipenem pivoxil hydrobromide is expected to have the potential to decrease the seizure threshold and will likely require renal dosage adjustment for patients with altered renal function due to high renal clearance. If approved in the United States, tebipenem pivoxil hydrobromide can serve as a potential oral antimicrobial option to decrease hospital length of stay and prevent hospital admissions due to resistant pathogens.

The rise of technology in healthcare has led to dramatic changes in approaches to patient care by healthcare professionals. The realm of digital health has created new opportunities for pharmacists to engage patients in clinical practice. Pharmacies and industry are increasingly integrating these innovations into their businesses and practice. This article highlights areas of digital health for pharmacists to be aware of, in particular regarding areas of medication adherence and disease management. Technology plays a massive role in our individual lives; it has morphed the human experience in ways that were simply unimaginable 50 years ago. We use technology in nearly every facet of our lives. From detecting an appropriate intensity with which to brush our teeth to counting calories lost through the course of a day, technology has made a major impact on individual health. The integration of technology into our everyday lives has changed the way we communicate, how we capture and share our lives with others, how we seek answers, and how we experience life overall. Given this change in the way people operate, it is important that pharmacists adapt to these trends and incorporate technology into daily practice. The incorporation of mobile devices and technology into healthcare has been coined as mobile health (mHealth), which falls under the broader spectrum of digital health.1 –4 Digital health focuses on the integration of mobile tools (e.g., smartphones), wearable devices, and telehealth to help personalize the treatment of patients through the widespread adoption of wireless technology. The idea of involving pharmacists in mHealth has been a topic of recent interest, due in large part to the potential ramifications for the profession.4 Today, patients are using the Internet to research their health questions and help guide their personal health choices, and some of the information they find can be misleading and unreliable. It is of the utmost importance that healthcare professionals ensure there are credible sources for patients to research their questions. As pharmacists, we can research and recommend tools to patients to help solve problems related to drug information, medication adherence, and access, which includes the recent rise of novel technological devices. All of our patients will have different comfort levels with technology; despite this spectrum, there is a place for everyone to feel comfortable using digital health tools. However, there are recent technological advances coming to the field, which are already providing a benefit to patients, ranging from mobile applications to wearable technologies to ingestible medications that notify providers of patient medication adherence. We seek to help pharmacists understand the different areas of digital health, which may have substantial influence on the realm of pharmacy practice in the years to come by addressing current and upcoming digital health developments.