Tuberculosis remains a very important issue of global health. The extrapulmonary tuberculosis forms (TBE) can be observed in less than 30% of all patients suffering from this disease. Pleural tuberculosis has a nonspecific presentation, which may delay the diagnosis. The polymerase chain reaction (PCR) applied for the identification of mycobacterial DNA facilitates a quick diagnosis in pleural tuberculosis. However, when the result is negative, and the patient is co-infected with other pathogens, the diagnosis may be delayed. We present a case of an immunocompetent patient with pleural tuberculosis and concomitant Flavimonas oryzihabitans bacteriemia, who was successfully treated with anti-tuberculosis treatment and antibiotic.