Background and objectives: Papillary thyroid carcinoma is the most frequent variety of all malignant endocrine tumors. It represents a heterogeneous malignancy with various clinical outcomes, emphasizing the need to identify powerful biomarkers with clinical relevance. Materials and Methods: Available gene expression data (level 3) for thyroid cancers were downloaded from the Cancer Genome Atlas (TCGA), followed by bioinformatic analyses performed on the data set. Results: Based on gene expression analysis, we were able to identify common and specific gene signatures for the three main types of papillary thyroid carcinoma (classical, follicular variant, and tall-cell). The survival rate was not significantly different among the main subtypes, but we were able to identify a biological adhesion signature with impact in patient prognostic. Conclusions: Taken together, the gene expression signature and particular adhesion signature, along with ITGA10 and MSLN in particular, could be used as a prognostic tool with important clinical relevance.

Introduction. Schizophrenia is a severe mental health disorder affecting almost 0.5% of the global population. Despite decades of research, it remains a debilitating condition that significantly impacts individuals’ quality of life (QoL) in aspects such as physical health, psychological well-being, independence, social relationships, beliefs, and environment. Current pharmacological treatment for schizophrenia consists of typical and atypical antipsychotics. Objective and methods. We conducted a cross-sectional study on a population of 109 patients who met the DSM-IV-TR or ICD-10 criteria for schizophrenia, aiming to assess their QoL, depending on the type of antipsychotic used (typical or atypical). Descriptive statistics were used to characterize the sample, and simple linear regression was used to evaluate the impact of the type of antipsychotic on the QoL. In addition, educational level, pathology, and previous treatment were considered as controlling factors. QoL was assessed using the EuroQol EQ-5D Quality of Life Scale (EQ-5D-3L) and the abbreviated version of the World Health Organization Quality-of-Life (WHO-QOL-BREF) Scale. Results. Patients treated with atypical antipsychotics (AA) presented higher overall scores on the EQ-5D-3L, indicating better QoL. In addition, there were significant associations between treatment type and gender, as well as employment status. However, no significant differences were observed in treatment history, marital status, educational level, or Positive And Negative Syndrome Scale (PANSS) results between the two groups. Conclusion. These findings highlight the need for individualized considerations of QoL when selecting the most suitable treatment approach for patients with schizophrenia. Further studies are warranted to provide precise guidance in tailoring treatments for these patients. Additionally, it is essential to conduct studies focusing on specific antipsychotic medications rather than broad categories to understand their distinct impacts on QoL and explore the complex relationships between antipsychotics and various influential factors in schizophrenia treatment

Context. Patients with radically treated differentiated thyroid carcinoma (DTC) undergo multiple episodes of iatrogenously-acquired hypothyroidism for the oncological follow-up. In some patients, this elevates high-sensitive C-reactive protein (hsCRP), a cardiovascular risk biomarker.Objective. We wanted to determine if there is any correlation between repeated hypothyroidism episodes, elevated hsCRP and an increased cardiovascular risk as stated through myocardial perfusion.Design. Between July 2014-January 2015, we analyzed serological levels of hsCRP for identifying our patients' cardiovascular risk; we performed a myocardial perfusion scintigraphy to observe the alterations.Subjects and methods. We included 27 patients (n=27), mean age of 52±10: CI (95%),14 female, all diseasefree after thyroidectomy, radioiodine ablation and chronic thyroid hormone treatment. We assigned the cardiovascular risk category for each patient according to hsCRP levels; all patients underwent a myocardial perfusion scintigraphy in order to determine the cardiac perfusion index (CPI).Results. hsCRP has been higher in > 65 years old male patients with more than 5 thyroid hormone withholdings. hsCRP is significantly associated with CPI (p=0.001). Spearman's rank correlation indicates a strongly positive linear correlation between these two parameters (r=0.745). Conclusions.Repeated thyroid hormonal withdrawals in patients with DTC during the long-term follow-up elevated hsCRP at cardiovascular risk levels, having an impact on myocardial perfusion.

The most frequent diagnoses were paranoid schizophrenia (388 patients) and undifferentiated schizophrenia (255 patients). All other ICD-10 diagnostic codes were used on 32 patients (Fig. 3).Patients were admitted for an average number of 17.44 days/patient (95% CI ± 0.03), generating an average cost of 7582 RON/patient (95% CI ± 428), (1660 EUR* (95% CI ± 93)).Data analysis by gender (Table 1) showed us that men had a significantly higher number of hospitalization days than women (p=0.01), which lead to a significantly higher cost of hospitalization for male patients (p=0.01). Our group generated a total health care cost of 5.1M RON (1.1 M EUR*). CONCLUSIONSSchizophrenia has a major economic impact, especially in male patients. Adequate treatments in out-patient clinics and better therapeutic adherence could lead to a decrease of economical burden, to an increased cost-efficiency rate and, finally, to a better patient care.