Despite the high prevalence of potential drug–drug interactions in pediatric intensive care units, their clinical relevance and significance are unclear. We assessed the characteristics and risk factors of clinically relevant potential drug–drug interactions to facilitate their efficient monitoring in pediatric intensive care units. This retrospective cohort study reviewed the medical records of 159 patients aged <19 years who were hospitalized in the pediatric intensive care unit at Seoul National University Hospital (Seoul, Korea) for ≥3 days between August 2019 and February 2020. Potential drug–drug interactions were screened using the Micromedex Drug-Reax® system. Clinical relevance of each potential drug–drug interaction was reported with official terminology, magnitude of severity, and causality, and the association with the patient’s clinical characteristics was assessed. In total, 115 patients (72.3%) were exposed to 592 potential interactions of 258 drug pairs. In 16 patients (10.1%), 22 clinically relevant potential drug–drug interactions were identified for 19 drug pairs. Approximately 70% of the clinically relevant potential drug–drug interactions had a severity grade of ≥3. Exposure to potential drug–drug interactions was significantly associated with an increase in the number of administrated medications (6–7 medications, p = 0.006; ≥8, p<0.001) and prolonged hospital stays (1–2 weeks, p = 0.035; ≥2, p = 0.049). Moreover, clinically relevant potential drug–drug interactions were significantly associated with ≥8 prescribed drugs (p = 0.019), hospitalization for ≥2 weeks (p = 0.048), and ≥4 complex chronic conditions (p = 0.015). Most potential drug–drug interactions do not cause clinically relevant adverse outcomes in pediatric intensive care units. However, because the reactions that patients experience from clinically relevant potential drug–drug interactions are often very severe, there is a medical need to implement an appropriate monitoring system for potential drug–drug interactions according to the pediatric intensive care unit characteristics.

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The goal of this study is to provide basic data to establish a foundation for the provision of safe drinkable water. The raw water of natural mineral water was analyzed to determine the quantities of anions (F -, Cl -, NO3-N -, and SO4 2-) and cations (Ca 2+ , K + , Mg 2+ , and Na + ) during the former and latter half of 2016. Analysis of the current quality of the raw water of natural mineral water among domestic manufacturers showed average anions contents of 0.46mg/L of fluorine, 8mg/L of chlorine ion, 1.5mg/L of nitrate nitrogen, and 12mg/L of sulfate ion. While the fluorine content was greater than the water quality criterion of 2.0mg/L at four points, the fluorine level was overall stable. The average cations contents included 21.3mg/L of calcium, 1.0mg/L of potassium, 3.4mg/L of magnesium, and 9.6mg/L of sodium. The chemical characteristics were compared among the major ions, and the results are presented in a piper diagram. The content ratio of cations was in the order of Ca 2+ > Na + >Mg 2+ >K + , whereas that of anions was in the order of SO4 2->Cl ->NO3-N ->F -. While the cations were slightly scattered, the anions were generally concentrated except for at a few points. The Ca-Na-HCO3 type was dominant overall in water sources from diorite, gneiss, and granite, while the Na-Mg-Ca-HCO3-Cl type was dominant in basalt sources. Mineral water manufacturers source their water under various conditions, including in-hole casing, excavation depth, and contact state of bedrock; even within the same rocky area, some differences in the water quality type can occur. When the depth of the water source was taken into account, the mean anions contents of F -, Cl -, NO3-N -, and SO4 2-were similar, with no significant differences according to depth. Of the cations, K + and Na + showed no significant differences across all the tubular wells, whereas Ca 2+ and Mg 2+ decreased in content with depth.

Nakdong river barrage was affected by artificial interference such as construction of port, industrial complex and estuary barrage. This change in Nadong river lead to environmental changes and affected the ability of barrier islands. Therefore, it is decided that the observation of changes in the Nakdong river estuary is very important. In this paper, the topographic change of the Nakdong river barrage observe based on Landsat TM, ETM+ images from 1984 to 2015. In addition, this study tried to conduct a comparative analysis on the area for change of sandy sediment according to tide level. This results could estimate height and volume about sandy sediment accumulated on the lower sand dune. Also, these results are expected to be the basis for prediction of the changing topography of the sand dune. The area of the average change in region 1,2,3 was calculated as 3,015 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

In this study, the concentrations of organophosphate flame retardants (OPFR) and perfluoroalkyl substances (PFAS) were investigated in raw water and treated water samples obtained from 18 drinking water treatment plants (DWTPs). The ∑13OPFR concentrations in the treated water samples (29.5–122 ng/L; median 47.5 ng/L) were lower than those in the raw water (37.7–231 ng/L; median 98.1 ng/L), which indicated the positive removal rates (0–80%) of ∑13OPFR in the DWTPs. The removal efficiencies of ∑27PFAS in the DWTPs ranged from −200% to 50%, with the ∑27PFAS concentrations in the raw water (4.15–154 ng/L; median 32.0 ng/L) being similar to or lower than those in the treated water (4.74–116 ng/L; median 42.2 ng/L). Among OPFR, tris(chloroisopropyl) phosphate (TCIPP) and tris(2-chloroethyl) phosphate (TCEP) were dominant in both raw water and treated water samples obtained from the DWTPs. The dominant PFAS (perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA)) in the raw water samples were slightly different from those in the treated water samples (PFOA, L-perfluorohexane sulfonate (L-PFHxS), and PFHxA). The 95-percentile daily intakes of ∑13OPFR and ∑27PFAS via drinking water consumption were estimated to be up to 4.9 ng/kg/d and 0.22 ng/kg/d, respectively. The hazard index values of OPFR and PFAS were lower than 1, suggesting the risks less than known hazardous levels.