ibstract The fission yeast Schizosaccharomyces pombe has proven useful for studying molecular interactions between a range *)f signal transduction components. We now report the first coexpression of a mammalian seven-transmembrane receptor and G-protein components in S. pombe. We selected the human neurokinin NK2 receptor together with its G-protein-signalling partoer G, for this study. Yeast membrane fractions showed high levels of NK2 receptor-binding activity (