In the current study, we examined whether participant motivation was associated with fluctuations of attentional engagement and performance over time. We gauged participants' motivation and depth of mind wandering as they completed the metronome response task to determine whether fluctuations in inattention (indexed by task performance and depth of mind wandering) would be related to fluctuations in motivation. As in prior work, we found that, with increasing time on task, (a) self-reported depth of mind wandering increased, (b) task performance decreased, and (c) motivation waned. Extending this work, we found an interaction between motivation and mind wandering such that mind wandering was negatively associated with task performance when motivation was low, but unrelated to performance when motivation was high. These results suggest that motivation may help improve task performance by reducing the depth of mind wandering, while also providing insulation from the negative effects of mind wandering, when it does occur.

The success of molecular research and its applications in both the clinical and basic research arenas is strongly dependent on the collection, handling, storage, and quality control of fresh human tissue samples. This tissue bank was set up to bank fresh surgically obtained human tissue using a Clinical Annotated Tissue Database (CATD) in order to capture the associated patient clinical data and demographics using a one way patient encryption scheme to protect patient identification. In this study, we determined that high quality of tissue samples is imperative for both genomic and proteomic molecular research. This paper also contains a brief compilation of the literature involved in the patient ethics, patient informed consent, patient de-identification, tissue collection, processing, and storage as well as basic molecular research generated from the tissue bank using good clinical practices. The current applicable rules, regulations, and guidelines for handling human tissues are briefly discussed. More than 6,610 cancer patients have been consented (97% of those that were contacted by the consenter) and 16,800 tissue specimens have been banked from these patients in 9 years. All samples collected in the bank were QC'd by a pathologist. Approximately 1,550 tissue samples have been requested for use in basic, clinical, and/or biomarker cancer research studies. Each tissue aliquot removed from the bank for a research study were evaluated by a second H&E, if the samples passed the QC, they were submitted for genomic and proteomic molecular analysis/study. Approximately 75% of samples evaluated were of high histologic quality and used for research studies. Since 2003, we changed the patient informed consent to allow the tissue bank to gather more patient clinical follow-up information. Ninety two percent of the patients (1,865 patients) signed the new informed consent form and agreed to be re-contacted for follow-up information on their disease state. In addition, eighty five percent of patients (1,584) agreed to be re-contacted to provide a biological fluid sample to be used for biomarker research.

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