Overlap and grouping functions are special kinds of non necessarily associative aggregation operators proposed for many applications, mainly when the associativity property is not strongly required. The classes of overlap and grouping functions are richer than the classes of t-norms and t-conorms, respectively, concerning some properties like idempotency, homogeneity, and, mainly, the self-closedness feature with respect to the convex sum and the aggregation by generalized composition of overlap/grouping functions. In previous works, we introduced some classes of fuzzy implications derived by overlap and/or grouping functions, namely, the residual implications R O -implications, the strong implications (G, N )-implications and the Quantum Logic implications QL-implications, for overlap functions O, grouping functions G and fuzzy negations N . Such implications do not necessarily satisfy certain properties, but only weaker versions of these properties, e.g., the exchange principle. However, in general, such properties are not demanded for many applications. In this paper, we analyze the so-called law of O-Conditionality, O(x, I(x, y)) ≤ y, for any fuzzy implication I and overlap function O, and, in particular, for R O -implications, (G, N )-implications, QL-implications and D-implications derived from tuples (O, G, N ), the latter also introduced in this paper. We also study the conditional antecedent boundary condition for such fuzzy implications, since we prove that this property, associated to the left ordering property, is important for the analysis of the O-Conditionality. We show that the use of overlap functions to implement de generalized Modus Ponens, as the scheme enabled by the law of O-Conditionality, provides more generality than the laws of T -conditionality and U -conditionality, for t-norms T and uninorms U , respectively. © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ inference processes via the generalized Modus Ponens (GMP) and Modus Tollens (GMT), carried out via the Zadeh's Compositional Rule of Inference [5]. 1 The GMP, which is the focus of this paper, can be implemented by a scheme enabled by the functional inequality called the Law of T -Conditionality, which, for a t-norm T and a fuzzy implication I, is stated by:In fact, (TC) means x * T (x → y) ≤ y, which generalizes the Modus Ponens x ∧ T (x → y) y to the fuzzy context [7, 8].In the literature, the studies on the T -Conditionality have been done just for the three main families of fuzzy implications, namely, R-, (S, N )and QL-implications. 2 R-implications are generalizations to [0, 1] of Boolean implications defined by the identity given, for a universe set X, bywhere A, B ⊆ X, and the intersection is generalized by a t-norm. This class of implications is related to a residuation concept from the intuitionistic logic. On the other hand, (S, N )-implications are generalizations to [0, 1] of the Boolean material implication defined aswhere ∨ and ¬ are...