The use of long-term intrathecal drug delivery for the treatment of intractable pain or intolerable medication adverse effects has expanded to include the treatment of patients with chronic or cancer-related pain. Important considerations for the use of intrathecal drug therapy include the appropriate selection of patients, delivery systems, and medications, as well as potential complications of therapy and quality-assurance measures necessary to ensure patient safety.

A need for profound methodological changes in the humanities, as well as possibility to build humanitarian technologies based on them, are considered in this paper. The concept of techno humanistics and culturonics underlines constructive rather than pure research beginning in humanities. The question is posed how these sciences are able to act on the subject of their study, what cultural practices can be built on the base of language, literature and philosophy study.

Interventional pain physicians frequently encounter patients with a treatment refractory "chronic pain syndrome." Such patients have chronically painful medical disorders that are complicated by a number of psychosocial factors, including premorbid or comorbid psychiatric and substance use disorders, physical deconditioning, dependency upon the healthcare system, and perceived impairments that are out of proportion to objective medical findings. A growing body of empirical evidence indicates that the effectiveness of medical interventions is diminished for patients with such psychosocial complications (1-3). There is