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The phytochemical screening of potentially efficient medicinal herbs is one of the current focus areas of modern pharmacochemistry. This work aims to analyze the phytochemical composition of the aboveground parts in three Stellaria species (S. bungeana, S. graminea, S. holostea). The study was conducted between May and July 2020 in the Moscow region of the Russian Federation. Yield values for raw herbal materials and density of stitchwort samples per 1 m2 (154 sites in total) were recorded, followed by a phytochemical analysis of the dry mass by chromatography. The maximum yield of S. bungeana was established to be 1.5 times higher than in two other species (p ≤ 0.05). In S. graminea, the maximum pectin concentration was 12 times higher than in S. holostea (p ≤ 0.001) and 0.5 times higher than in S. bungeana (p ≤ 0.05). The number of polysaccharides in S. bungeana was 14 times higher than in S. graminea (p ≤ 0.001) and two higher than in S. holostea (p ≤ 0.05). Hemicellulose content of S. bungeana extract was twice as high as that of other species (p ≤ 0.05). Tannins in S. graminea were found two times more often than in S. holostea (p ≤ 0.05) and eight times more often in S. bungeana (p ≤ 0.01). Vitamin C content in S. graminea was two times greater than in the other two stitchwort species (p ≤ 0.05). Stitchwort is a common, widespread plant that makes it easy to collect without harming plant communities. Biologically active substances (polysaccharides, vitamin C, tannins, and pectins) were found in the composition of all stitchwort species with a preventive and therapeutic effect on the human body. The concentration of tannins and vitamin C is maximal in S. graminea extract, amounting to 2.6% and 45.9%, accordingly. The extract from S. bungeana contains a lot of hemicellulose (13.2%) and polysaccharides (7.2%). No high concentration of these substances was recorded in S. holostea, which makes this species the least pharmaceutically valuable. S. graminea and S. bungeana plants can be recommended for pharmaceutical processing due to the high concentrations of vitamin C, pectins, tannins, polysaccharides, and hemicellulose.

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The human microbiome is an integral part of the body, playing a crucial role in metabolism, energy homeostasis, the regulation of the immune system, and others. The study aims to examine the effect of probiotic ointment on the qualitative composition of the lesional skin microbiome in patients with atopic dermatitis. The study population consisted of 110 patients aged 20 to 45 years with mild atopic dermatitis (AD). The patients were divided into two groups. One group received four different medications: levocetirizine dihydrochloride, enterosgel, topical Tizol gel, and topical 1% hydrocortisone ointment. The other group received a similar treatment with four different medications: levocetirizine dihydrochloride, enterosgel, topical Tizol gel, and topical probiotic ointment. The treatment period was one month. After treatment, the frequency and intensity of the main AD symptoms significantly decreased. A load of S. aureus fell in the probiotic-treated group from 73.4% to 29.1% (p<.05). In the standard-treated group, the S. aureus load decreased from 78.2% to 43.6% (p<.05). The study found that the standard treatment without probiotics helped to decrease S. aureus colonisation in AD patients by 2.00 times (p<.05), whereas using the probiotic ointment reduced S. aureus colonisation by 3 times (p<.05).