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The aim of the study was to investigate for the effect of different drugs immediately after parturition on the reduction of retention of placenta in selected cows. One hundred pregnant cows from members of Community Based Dairy Veterinary Foundation, Shikalbaha, Potiya, Chittagong were included in this study belonged to two breeds viz, cross bred and local, aged 3-8 years, calved 1-5 times with BCS 2-3.5. The cows were divided into five groups; group L (n=20) treated with oxytocin 50 iu/intramuscular, group IL (n=20) treated with calcium 400 ml/intravenous, group III: (n=20) treated with methyl ergometrine maleate 20 mg/intramuscular, group IV: (n=20) treated with oxytocin 50 iu/ intramuscular plus calcium 400 ml/ intravenous and group V: (n=20) served as non-treated control. The incidence of retained fetal membrane was 35% in control group, while that of pooled treatment group had 15%. This reduction was significant (P<0.05). In the present study, there was no significant difference among the different treatment groups on the prevention of retention (P>0.05). The incidence of retained fetal membrane was affected by the age and breed of cows (P<0.05). However, this effect was override by treatment and injection of drugs immediately after parturition decreases the incidence of retention of placenta in cows.

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