In the group of patients with both renal cell carcinoma and arterial hypertension, their hypertension was resolved after they underwent nephrectomies. In conclusion, our data suggest that renal cell carcinomas may cause arterial hypertension.

showed significantly higher complication rate (n = 20, 36.4% vs. n = 19, 27.1%, p = 0.007), especially intraabdominal fluid collection (n = 6, 10.9% vs. n = 1, 1.4%), and wound infection (n = 6, 10.9% vs. n = 2, 2.9%). AAF group showed lower incidence of postoperative ileus (n = 3, 5.5% vs. n = 11, 15.7%) with statistically marginal significance (p = 0.090). Conclusions: Well-designed randomized controlled trials of anti-adhesive product will be needed for evaluation of effect on postoperative ileus after major HPB surgery.

The objective of this study was to present some clinical and radiological manifestations of PNS in relation to bronchogenic carcinoma (BC) and to evaluate the usefulness of imaging findings in the diagnosis of asymptomatic BC. In the study group of 204 patients (146 male and 58 female) with proven bronchogenic carcinoma, PNS was present in 18 (8.62%) patients. The patients with PNS were divided into two groups. The first one consisted of 13 (72.2%) patients with symptoms related to primary tumours while the second one consisted of 5 (27.7%) patients with symptoms, at initial appearance, indicative of disorders of other organs and systems. The predominant disorder was Lambert-Eaton Syndrome, associated with small-cell carcinoma. Endocrine manifestations included: inappropriate antidiuretic hormone production syndrome (small-cell carcinoma), a gonadotropin effect with gynaecomastia and testicular atrophy (planocellular carcinoma, small-cell carcinoma), a case of Cushing Syndrome (small-cell carcinoma), and hypercalcaemia, due to the production of the parathyroid hormone-related peptide, which was associated with planocellular carcinoma. A rare case of bilateral exophthalmos was found as PNS at adenocarcinoma. Digital clubbing and hypertrophic osteoarthropathy (HO) were associated with planocellular and adenocarcinoma, while clubbing was much more common than HO, especially among women. The differences between the two groups were related to the time of PNS appearance. In the first group, PNS occurred late on in the illness, while in the second group, PNS preceded the diagnosis of BC. Alternatively, the disappearance of a clinical or a radiological manifestation of PNS after surgery or chemotherapy may be an indicator of an improvement in health or PNS may be the first sign of illness recurrence. Radiological manifestations of PNS in asymptomatic patients may serve as a useful screen for identifying primary BC. In symptomatic patients, it may be an indicator of a higher likelihood of metastatic disease.

Sažetak: Uvod: Karcinom pankreasa je najčešće lokalizovan u glavi pankreasa. Ima visok mortalitet, najčešće zbog kasne kliničke manifestacije bolesti i odsustva ranih simptoma, kao i visokog procenta recidiva posle hiruške terapije i rezistencije na konvencionalnu onkološku terpaiju. Faktori rizika za nastanak karcinoma pankreasa su pušenje, prekomerno unošenje masti i mesa, gojaznost, dijabetes mellitus, hronični pankreatitis. Neke studije ukazuju na povezanost hronične infekcije hepatitisom B sa pojavom karcinoma pankreasa. Cilj rada je ukazivanje na značaj primarne prevencije i izmene stila života s obzirom da ne postoji skrining program za rano otkrivanje bolesti. Prikaz slučaja: Pacijent muškog pola, star 51 godinu žali se na nelagodnost u epigastrijumu koja traje nekih desetak dana, ređe stolice, gubitak na telesnoj težini 10 kilograma za godinu dana i žutu prebojenost beonjača. Boluje od hroničnog hepatitisa B, šećerne bolesti i od hipertenzije. U porodičnoj anamnezi majka boluje od DM tip 2 i HTA, otac bolovao od sarkoma. Zaposlen, oženjen, troje dece; pušio je 20 godina po 10-15 cigareta, ne puši unazad 5 godina; Alkoholna pića konzumira povremeno u umerenim količinama. Negira alergije na hranu i lekove. Inspekcijom se uočava ikterična koža i sklere. Abdomen je u ravni grudnog koša, palpatorno mek, lako bolno osetljiv u epigastrijumu. Jetra se palpira 3 centimetra ispod desnog rebarnog luka. Ostali nalaz je uredan. Laboratorijske analize: povišene transaminaze, GGT, alkalna fosfataza. Vrednost tumorskog markera CA19.9 je 550. Na kompjuterizovanoj tomografiji (CT) abdomena je nadjeno uvećanje glave pankreasa sa tumorskom promenom 25mm. Pacijent je podvrgnut hirurškoj intervenciji u dva navrata, histopatološki nalaz (HP) je bio: adenocarcinoma ductale invasivum capitis pancreatis. Nakon toga je sprovedena hemioterapija po protokolu 5-FU/LV. Nakon IV ciklusa savetovana je hemioiradijacija. Nakon sprovedene terapije redovno se kontroliše skoro 3 godine i nema znakova recidiva bolesti. Zaključak: I pored primenjene terapije karcinom pankreasa i dalje ima visok mortalitet. Treba raditi na modifikaciji faktora rizika i izmeni stila života, kao i sprovođenje mera zaštite radi sprečavanja nastanka hepatitisa B uključujući i vakcinaciju protiv B hepatitisa kod osoba koje su u riziku.