Introduction/Objective. Urothelial carcinoma is the most commonly diagnosed malignancy of urinary bladder in clinical and pathohistological practice where various prognostic factors play significant role. One of the most important pathohistological prognostic factors is the intensity of immunohistochemical staining. Among various immunohistochemical markers that have been proven to influence disease progression and patient?s survival, role of Ki-67 and GATA3 in prediction of disease prognosis has not been completely clarified yet. The aim of this study was to determine the predictive value of GATA3 and Ki-67 mutual expression in urothelial carcinoma. Methods. 80 patients were included in this study, where 4 groups were formed based on the pathological stage of urothelial carcinoma. After using preferred antibodies, their staining intensity was analyzed semiquantitatively. Results. Results showed that there was statistically important significance between type of urothelial carcinoma, pathological stage and invasiveness and different grades of GATA3 expression, as well as statistically important significance between type of urothelial carcinoma and pathological stage and different grades of Ki-67 expression. The regression model showed low value of GATA3 and Ki-67 mutual expression. There was also a statistical significance considering pathological stage and invasiveness of the tumor in survival analysis. Conclusion. Predictive value of GATA3 and Ki-67 mutual expression resulted as low from this study, but to our knowledge it was the first one to examine their predictive capability on biopsy and transurethral resection specimens.

Introduction. Inflammatory myofibroblastic tumor is a mesenchymal neoplasm with an aggressive potential and a tendency for recurrence. It is known to occur in a variety of locations, including the female genital tract. The objective of this study was to provide an overview of the clinical, histopathological, immunohistochemical and molecular features of the inflammatory myofibroblastic tumor, emphasizing potential diagnostic pitfalls in the female genital tract. Case Report. The diagnosis of an inflammatory myofibroblastic tumor of the right ovary with extension to the right parametrium and peritoneal adipose tissue was made in a 74-year-old patient after a detailed laboratory testing, computed tomography and histopathological examination. Conclusion. This case report presents an unusual experience of specialists in everyday practice, with a successful combination of skills in gynecological surgery and pathology. Inflammatory myofibroblastic tumor is a diagnostic challenge that needs to be considered in the differential diagnosis of tumors of both the ovary and the entire female genital tract.