Complex comblike block copolymers of various architectures containing polystyrene, PS, and polyisoprene, PI, or polybutadiene, PB, components were synthesized by anionic polymerization high-vacuum techniques and the macromonomer strategy. Their micellization behavior was studied in n-decane, a selective solvent for the PI or PB blocks, and in N,N′-dimethylacetamide, DMA, selective for the PS blocks. Utilizing static and dynamic light scattering techniques, parameters such as the aggregation number and the hydrodynamic radius were determined. On the basis of these results, structural parameters of the micelles, i.e., core and corona radii as well as core-corona interfacial area, were calculated. The thermal stability of the micelles was also examined in both selective solvents. The macromolecular architecture was found to have a considerable effect on the micellization behavior of the block copolymers.

We synthesized a series of well-defined poly(dl-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) (PDLLA-b-PDMAEMA) amphiphilic diblock copolymers by employing a three-step procedure: (a) ring-opening polymerization (ROP) of dl-lactide using n-decanol and stannous octoate, Sn(Oct)(2), as the initiating system, (b) reaction of the PDLLA hydroxyl end groups with bromoisobutyryl bromide, and (c) atom transfer radical polymerization, ATRP, of DMAEMA with the newly created bromoisobutyryl initiating site. The aggregation behavior of the prepared block copolymers was investigated by dynamic light scattering and zeta potential measurements at 25 degrees C in aqueous solutions of different pH values. The hydrophobic drug dipyridamole was efficiently incorporated into the copolymer aggregates in aqueous solutions of pH 7.40. High partition coefficient values were determined by fluorescence spectroscopy.

Θεξκνθξαζία παιψδνπο κεηάπησζεο DLS Γπλακηθή ζθέδαζε θσηφο laser SEC ή GPC Υξσκαηνγξαθία απνθιεηζκνχ κεγεζψλ (Size Exclusion Chromatography) ΝΜR Ππξεληθφο καγλεηηθφο ζπληνληζκφο (Nuclear Magnetic Resonance) MDSC Γηαθνξηθή ζεξκηδνκεηξία ζάξσζεο κε δηακφξθσζε UV-vis Τπεξηψδεο-νξαηφ FT-IR Τπέξπζξν κε κεηαζρεκαηηζκφ Fourier AFM Μηθξνζθνπία αηνκηθψλ δπλάκεσλ (Atomic Force Microscopy) SAXS θέδαζε αθηίλσλ Υ ζε κηθξέο γσλίεο (Small Angle X ray Scattering) Μ n Μέζν κνξηαθφ βάξνο θαηά αξηζκφ M w Μέζν κνξηαθφ βάξνο θαηά βάξνο Ι = Μ w /M n πληειεζηήο θαηαλνκήο κνξηαθψλ βαξψλ R h Τδξνδπλακηθή αθηίλα 4.1.5.2 χλζεζε ησλ νκνπνιπκεξψλ θαη ησλ ηξηζπζηαδηθψλ ζπκπνιπκεξσλ κε ηε ρξήζε ηνπ απαξρεηή 1,4-(2-βξσκντζνβνπηπινυιν