Objective. Arterial hypertension (HTN) is important due to its high prevalence, morbidity, and mortality rates. Calcium channel blockers (CCBs) are the first-line antihypertensive drugs. HTN can lead to heart failure (HF) by causing hypertensive left ventricular hypertrophy (HTN LVH). CCBs are recommended for the treatment of HTN LVH. The aim of the paper is to analyze the status of CCBs regarding 1) HTN LVH treatment and 2) capability to prevent HTN-induced HF in the guidelines. Methods. A narrative review is used for this paper. A search of the following databases was conducted: Medline, Scopus, Science Direct, Springer, SAGE, Wiley, Oxford Journals, Cambridge, and Google Scholar. Results. CCBs are effective antihypertensive drugs. CCBs are also a very good therapeutic option for HTN LVH because they are capable of causing reverse LVH remodeling. Consequently, we may expect that CCBs would prevent HF. However, evidence suggests CCBs confer less protection from HF than other first-line antihypertensive drugs. A negative inotropic action of non-dihydropyridine CCBs may contribute to suboptimal protection against HF. This discrepancy is clinically relevant because CCBs are in one of the two recommended (single-pill) combinations for the initial treatment of the HTN population. HTN LVH precipitates HF. Conclusion. CCBs are somewhat inferior to renin-angiotensin-aldosterone system blockers but still very good in HTN LVH regression; consequently, CCBs are expected to protect from HF. On the contrary, CCBs protect from HF less than other first-line antihypertensive drugs. This discrepancy needs a clear explanation in order to improve clinical practice.
The authors of this paper examine the phenomenon of emotionalization of criminal law, which emanates in three stages: in the legislative process, within the content of respective legal provisions, and in criminal procedure. The third stage is well-identified as such and, here, procedural principles aim to guarantee impartiality of the judge. Regarding the content, discussions about negative feelings were part of the dogmatical upgrading of hate as an obligatory aggravating circumstance envisaged in prior amendments to the Serbian Criminal Code. On the other hand, the emotionalization of legislative procedure, perceived as the process of adopting and amending criminal legislation in an emotionalized context, has largely remained in the background. After elaborating on the relevance and topicality of this issue, the authors connect it with the basic goals of law and legitimacy of state power, provide various definitions and explain the notion of emotions by referring to examples from comparative law. Thereupon, the concept of emotionalization of law is analyzed with reference to the legal provisions from the latest amendments to the Criminal Code of the Republic of Serbia (2019).
Savremeni jusnaturalizam promoviše stav da se prirodno pravo sastoji od tri grupe principa. Prva i najvažnija grupa principa rukovodi ljudske izbore i postupke ka ostvarivanju osnovnih ljudskih dobara, poput života, znanja, prijateljstva, koja su po sebi vredna. Druga grupa principa usmerava ljude ka valjanim izborima, koji ih vode prema osnovnim dobrima. Neki od tih principa su da treba imati jedan racionalan i koherentan životni plan, da treba delati na opšte dobro zajednice, da treba u svakoj radnji i aktu poštovati sva osnovna ljudska dobra, da treba slediti naloge svoje savesti itd. Proizvod svih ovih principa jeste moralnost. Pošto ovi principi rukovode od suda o tome šta su osnovna dobra do zaključka o tome šta je ispravno da se čini ovde i sad, oni se mogu nazvati i principima praktičke razboritosti. Treća grupa principa, koji se mogu nazvati i posebnim moralnim normama, odnosi se na dozvoljavanje ili zabranjivanje određenih ljudskih ponašanja, poput zabrane ubistva nedužne osobe. Budući da pravo ima svoju moralnu svrhu, norme pozitivnog prava treba da budu utemeljene u prirodnom pravu. Ova stara koncepcija ima dugu istoriju razvitka počev od Aristotela, preko Tome Akvinskog, sve do današnjih dana. U okviru moderne teorije prirodnog prava, ta koncepcija za osnovnu svrhu ima utvrđivanje kriterijuma kako norme pozitivnog prava treba da proističu iz prirodnopravnih principa.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.