Summary1. Renin-like activity was found in rat submaxillary glands. 2. This activity was destroyed by boiling, was non-dialyzable and showed an optimum at approximately 500 C. 3. Renin-like activity in the submaxillary gland was not diminished 24 h after nephrectomy but was considerably reduced after ligature of the submaxillary duct. 4. Renin-like activity in the submaxillary gland was reduced following fooddeprivation, water-deprivation or hypovolemia. 5. Renin-like activity in the rat submaxillary gland was increased after isoproterenol administration but not following pilocarpine. 6. Renin-like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCI, as well as following adrenalectomy. 7. Chlorothiazide and ouabain increased submaxillary renin-like activity but diazoxide did not affect this activity.

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