Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of the water extract of Clinopodium gracile Matsum var. multicaule (WECG) on the mast cell-mediated allergic inflammation and studied the possible mechanism of action. WECG inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated cutaneous anaphylaxis in a dose-dependent manner. WECG dose-dependently reduced histamine release from rat peritoneal mast cells and human mast cells. The inhibitory effect of WECG on histamine release was mediated by the modulation of intracellular calcium. In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. The inhibitory effect of WECG on these proinflammatory cytokines was nuclear factor-kappaB (NF-kappaB) dependent. Our findings provide evidence that WECG inhibits mast cell-derived allergic inflammation and involvement of calcium and NF-kappaB in these effects.

Intelligent service robots leading the future market are robots which assist humans physically, mentally, and emotionally. Since intelligent service robots operate in a tightly coupled manner with humans, their safe operation should be an inevitable consideration. For this safety, real-time capabilities are necessary to execute certain services periodically. Currently, most robot components are being developed based on Windows for the sake of development convenience. However, since Windows does not support real-time, there is no option but to use expensive third-party software such as RTX and INTime. Also since most robot components are usually execute in user-level, we need to research how to support real-time in user-level. In this paper, we design and implement how to support real-time for components running in user-level on Windows using RTiK which actually supports real-time in kernel level on Windows.

As the system development environment moves from single core to multi core-based platforms, it becomes more important to maintain compatibility between single core-based implementations and multi core-based implementations. Moreover, it is very important to support real-time on multi core platforms especially in cases of embedded software or test equipments which need real-time as well as correctness. Since Windows operating system dopes not support real-time in itself, it has been supporting real-time using expensive third-party solutions such as RTX or INtime. So as to reduce this kind of development expenses, in this paper, we propose RTiK-MP(Real-Time implant Kernel-Multi Processor) which supports real-time on Windows using the Local APIC of x86 architectures, and evaluate the performance of the proposed RTiK-MP after deploying it on portable missile test equipments.

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