Traditional college English lectures, writing, and translation over wireless networks have several problems. As a consequence, research and development for fifth-generation (5G) technologies are already beginning. High data speeds, decreased latency, energy savings, low cost, increased system capability, and large-scale device connectivity are all characteristics of 5G, the fifth generation of mobile communication technology. The 5G network is a wireless network interaction approach for the digital cellular network that allows for massive volumes of data traffic and a large number of wireless connections. The newest 5G technologies must be incorporated into the curriculum to attain higher-order educational capacities. Educators must fully use network resources, especially 5G network interaction tools, to improve English lecture, writing, and translation, as the fast expansion of 5G network interaction methods provides a fresh viewpoint for English lecture, writing, and translation. In this paper, we design a 5G-enabled Genetic Algorithm- (GA-) based approach for college English lectures, writing, and translation. The proposed method can promote resource sharing, empower teacher-student connections, and improve students’ overall English writing performance by researching this novel kind of network. The proposed method is further improved by incorporating 5G network-dependent English writing and interaction tools. Experimental results reveal that the proposed method outperforms state-of-the-art methods.