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Background: Seeking for new specific and effective drugs against Corona virus Diseases-2019 (COVID-19) is of great important. This study describes the efficacy of remdesivir with supportive care alone in the treatment of critically sick adult and child COVID-19 patients. Method: This study was a one-blind placebo-controlled, randomized clinical trial in adults (aged≥18 years) and children (aged≤12 years) in Iran. Patients were included if they had positive PCR test for SARS-CoV-2 infection , O2 saturation ≤88%, and compatible symptoms. All participants received standard care following national treatment guidelines. The treatment group received remdesivir (200 mg IV on day 1 and followed by 100 mg in single daily infusions). The control group received standard care and identically volume of placebo infusions (Water for injection) for 5 days. For pediatric patients, the intervention group received remdesivir (5mg/kg on the first day and then 5.2 mg/kg on days 2 to 5). Discharge from the hospital within 10 days of first treatment be considered as the primary endpoint of the study. Admission in the intensive care unit (ICU) be considered as original secondary endpoint of the study. Results: 141 patients were enrolled and randomly assigned to two group (adults; 54 patients in the intervention group vs. 52 patients in the control group, and children; 17 patients in the intervention group vs. 18 patients in the control group). The mean time from the first symptoms until the referral to the hospital in adults patients were 5.61±2.67 day and 4.80±1.48 day for intervention and control groups respectively. The mean time from the first symptoms until death was reported significant and was longer for intervention group than the control group (24.83±11.25 vs 10.50±2.42 day; p value=0. 012). For children who receive remdesivir, the mean time between admission until death was reported significant, as the finding highlighted longer time duration for intervention group (13.55±0.72 vs 10.66±0.57 day; p value=0. 016). The mechanical ventilation was used in 17 patients (100%) and 18 patients (100%) in intervention and control groups respectively (p value=0.853). Discussion: Among patients with critical COVID-19, those randomized to a 5-day receiving of remdesivir did have a statistically significant difference in clinical status compared with control group in both adults and children groups. Keywords: Infectious disease, COVID-19, Mechanical ventilation, treatment, remdesivir No. IRCT20200405046953N1