The generation of reactive oxygen species (ROS) is an important mechanism of nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead of producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics that can inhibit •OH generation. We theorized for the first time that the multienzyme-like activities of PBNPs were likely caused by the abundant redox potentials of their different forms, making them efficient electron transporters. To study the ROS scavenging ability of PBNPs, a series of in vitro ROS-generating models was established using chemicals, UV irradiation, oxidized low-density lipoprotein, high glucose contents, and oxygen glucose deprivation and reperfusion. To demonstrate the ROS scavenging ability of PBNPs, an in vivo inflammation model was established using lipoproteins in Institute for Cancer Research (ICR) mice. The results indicated that PBNPs hold great potential for inhibiting or relieving injury induced by ROS in these pathological processes.

No abstract

No abstract

A novel magnetic hydrogel is formed via the field-directed assembly of magnetic nanomaterials during the gelation process. The novel magnetic hydrogel exhibits direction-dependent thermogenesis in an alternating magnetic field. The specific absorption rate value in the direction along the assemblies can be 2.1-fold as much as that in the direction normal to the assemblies while the heating rate is 6-8-fold. Due to the anisotropic thermogenesis, the novel magnetic hydrogel also shows a direction-dependent release of drugs that has a 3.4-fold difference between the two directions.

No abstract