In the initiation and evolution of human cancers, circular RNAs (circRNAs) act as crucial regulators.

This study explored the function and mechanism of RAD50 interactor 1 (RINT1), Zeste white 10 (ZW10) or nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) in cell growth of colon cancer. The mRNA expression of RINT1 was suppressed in patients with colon cancer. In addition, disease free survival (DFS) in colon cancer patients with high expression of RINT1, ZW10 and NAG-1 were promoted compared with colon cancer patients with low expression of RINT1, ZW10 and NAG-1. Over-expression of RINT1, ZW10 or NAG-1 reduced colon cancer cell growth, migration and invasion in vitro model. In contrast, down-regulation of RINT1, ZW10 or NAG-1 promoted colon cancer cell growth, migration and invasion in vitro model. Over-expression of RINT1 promoted while down-regulation of RINT1 suppressed ZW10 and NAG-1 expression. Following knockdown of ZW10 and NAG-1 protein expressions, RINT1 induced changes of colon cancer cell growth, migration and invasion were inhibited. Taken together, it is indicated that RINT1 is a new suppression target to reduce cell growth, migration and invasion of colon cancer by targeting ZW10/NAG-1.

No abstract