Background: The reproducibility of radiomic features is essential to lung cancer detection. This study aimed to investigate the reproducibility of radiomic features of pulmonary nodules between low-dose computed tomography (LDCT) and conventional-dose computed tomography (CDCT).Methods: A total of 105 patients with 119 pulmonary nodules [39 ground-glass nodules (GGNs) and 80 solid nodules] who underwent LDCT and CDCT were retrospectively studied between September 2019 and November 2020. Pulmonary nodules were manually segmented and 1,125 radiomic features (shape, firstorder intensity, texture, wavelet, and Laplacian of the Gaussian features) were extracted from both LDCT and CDCT images. The concordance correlation coefficient (CCC) was used to evaluate the reproducibility of these radiomic features.Results: Of the 1,125 radiomic features considered, 35.5% (399 of 1,125) and 41.5% (467 of 1,125) were reproducible (CCC ≥0.85) for GGNs and solid nodules, respectively. The intensity, texture, and wavelet features of solid nodules were more reproducible than those of GGNs. The mean CCC values for intensity and texture features of solid nodules were of 0.85 and above, whereas the mean values for those of GGNs were of less than 0.85. After Gaussian kernel (σ =2) preprocessing, the CCC of intensity and texture features of GGNs improved from 0.77 to 0.90, and 84.9% (79 of 93) of the radiomic features were reproducible (mean CCC increase from 0.84±0.13 to 0.92±0.08 for intensity features, and from 0.75±0.15 to 0.89±0.11 for texture features). Wavelet features had the lowest CCCs for both GGNs and solid nodules. Conclusions:The majority of the radiomic feature classes of solid pulmonary nodules have a high level of reproducibility between LDCT and CDCT. However, LDCT should not be used as an alternative to CDCT in the radiomic study of GGNs.

BACKGROUNDPulmonary edema is a severe complication in patients with acute myocardial infarction which indicates the development of heart failure (HF) and poor prognosis. However, subclinical pulmonary edema after acute ST-segment elevation myocardial infarction (STEMI) without HF has not received enough attention in clinical practice. We aimed to investigate the prognostic value and associated clinical characteristics of subclinical pulmonary edema after acute STEMI without HF detected by chest computed tomography (CT).METHODSA total of 276 patients with acute STEMI without HF who underwent chest CT were included in this study. K-means clustering analysis was performed to classify the patients into different subgroups based on the mean lung density. Clinical characteristics of the different subgroups were compared and used to establish a machine learning model for discriminating between them. Relative risk (RR) for major adverse cardiovascular events (MACEs) during hospitalization was compared between the subgroups.RESULTSThe patients were classified into two subgroups. Subgroup 2 showed higher mean lung density than subgroup 1 (median [IQR], −727 [−747, −704] vs. −806 [−826, −785] HU, P < 0.001), with significantly higher levels of cardiac enzymes and numbers of inflammatory cells and significantly worse left ventricular function than subgroup 1. In the model analysis, the most important clinical characteristics were the levels of cardiac enzymes, numbers of inflammatory cells, and left ventricular function. The risk for MACEs was higher in subgroup 2 than in subgroup 1 (RR, 2.12; P = 0.002).CONCLUSIONSSubclinical pulmonary edema after acute STEMI without HF was mainly associated with elevated levels of cardiac enzymes, followed by increased numbers of inflammatory cells and worse left ventricular function. In addition, subclinical pulmonary edema provided crucial prognostic information for patients during hospitalization.

In this report, we present a case study of an extremely rare left sinus Valsalva aneurysm (SVA) rupture into the left-ventricular myocardium. Acute ozone inhalation and long-term hypertension are possible contributors to the condition. Utilizing multimodal cardiovascular imaging techniques [echocardiogram, computed tomography (CT), and cardiac magnetic resonance (CMR)], a large, left-ventricular, intramural pseudoaneurysm (IPA) arising from the ruptured left SVA, was clearly observed anatomically and functionally. Subsequently, our patient underwent patch repair and valvoplasty which offered an excellent prognosis. This report describes the manifestation of the ruptured left SVA and its possible etiology. This case also emphasizes the need for multimodal imaging for subsequent surgical repair.

No abstract