Herein, we report a general strategy for the rational design of an efficient organic photocatalyst, and we describe a robust method for the direct C(sp 3 )−H carbamoylation of saturated aza-heterocycles under mild conditions by using a naphthalimide (NI)-based organic photocatalyst. This protocol provides a concise and practical approach for the rapid installation of a valuable amide bond onto pharmaceutically useful saturated aza-heterocycles to access a wide range of cyclic α-amino amides. A series of mechanism investigations have demonstrated this transformation undergoes a visible-light photocatalytic, oxidative Ugi reaction process.

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Photoinduced C(sp3)–H phosphorylation was reported to rapidly install a phosphoryl group on the biologically useful saturated aza-heterocycles with commercially available diarylphosphine oxide reagents by a novel organic photocatalyst.

A highly efficient synthesis of unsymmetrical 3,3’-diindolylmethanes bearing various substituents has been developed by palladium-catalyzed cascade Heck/cyclization reaction. In this transformation, precursors allenamides and o-ethynylanilines were utilized to generate in...