Iron is indispensable in numerous biologic processes, but abnormal iron regulation and accumulation is related to pathological processes in cardiovascular diseases. However, the underlying mechanisms still need to be further explored. Iron plays a key role in metal-catalyzed oxidative reactions that generate reactive oxygen species (ROS), which can cause oxidative stress. As the center for oxygen and iron utilization, mitochondria are vulnerable to damage from iron-induced oxidative stress and participate in processes involved in iron-related damage in cardiovascular disease, although the mechanism remains unclear. In this review, the pathological roles of iron-related oxidative stress in cardiovascular diseases are summarized, and the potential effects and mechanisms of mitochondrial iron homeostasis and dysfunction in these diseases are especially highlighted.

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Background Alveolar recruitment maneuvers (ARMs) is an important part of lung-protective ventilation strategies (LPVSs), but the optimal duration and interval Remain unclear. Methods Patients:252 patients who underwent holmium laser lithotripsy surgery and meet inclusion criteria were included and randomized into three groups based on the duration and frequency of ARMs (Regular, one 30 s ARM (RARMs); Improved and intermittent, three 10s ARMs (IARMs); and Control (C), no ARMs).Interventions: Groups R and I received ARMs at 20 cmH2O pressures every 30 min. All patients received the same anesthesia and mechanical ventilation. Measurements:Outcomes included heart rate and mean arterial pressure changes during ARMs and postoperative pulmonary complications (PPCs) within the first 7 postoperative days. Main results Incidences of PPCs in groups R(7.1%) and I (5.0%)were slightly lower than those in group C (8.9%).This indicated the potential to reduce lung injury. Heart rate and mean arterial pressure fluctuations during ARMs were significantly higher in groups R and I than in group C (P < 0.01). The rate of blood pressure decrease was significantly higher in group R than in group I (P < 0.01). Conclusions IARMs can reduce cycle fluctuations than RARMs in patients Undergoing holmium laser lithotripsy surgery with laryngeal mask general anesthesia. Low tidal volume ventilation and low PEEP combined with ARM did not significantly reduce the incidence of PPCs in healthy lung patients, but tended to reduce lung injury. Trial registration The study was registered on the Chinese Clinical Trial Registry. (ChiCTR2000030815,15/03/2020). This study was approved by the ethics committee of Chengdu Fifth People’s Hospital with approval number(2020–005(Study)-1).

Background: Dezocine is a novel opioid receptor-antagonistic analgesic, which is widely used in clinic work. However, its usage in cesarean section is rare.Case presentation: A 28-year-old woman of 38 weeks' gestation (163cm, 79kg) underwent emergency cesarean section because of pelvic outlet stenosis in November 2021. There was no history of preeclampsia, anticoagulation, or hemorrhagic diathesis. The most recent electrocardiogram (ECG) during pregnancy was sinus tachycardia, and the heart rate (HR) was 108 beats/min. After the accomplishment of spinal anesthesia, the cesarean section started smoothly. After the fetus was delivered, the patient complained of pain when suturing the skin. The anesthesiologist gave her dezocine 5mg and the parturient presented with hypertensive crisis merging paroxysmal supraventricular tachycardia (PSVT). The fastest HR was 178 beats/min and the highest blood pressure (BP) was 190/128mmHg. After Esmolol 20mg and Urapidil 12.5mg were administrated, her HR and BP returned normal range 3min later. After observation, the patient returned to the ward one hour later and left hospital after 5 days. The patient denied the history of PSVT and hyperthyroidism.Conclusion: Nowadays，dizocine has been widely used in the area of postoperative analgesia. However, its usage is rare in obstetrics and gynecology. The malignant adverse reactions of dizocine needs to be highly vigilant.

Background: To systematically evaluate the effects of ultrasound-guided lung recruitment maneuvers(U-LRM) on he incidence of perioperative atelectasis and the Lung ultrasound scores(LUS) with adults undergoing general anesthesia. Materials and methods we searched relevant studies in CNKI,Wanfang,CBM,PubMed, EMBASE, and the Cochrane Library up to December ,2022. Based on the inclusion and exclusion criteria, the literatures were strictly screened, and meanwhile the Revman 5.4 software was used to evaluate the migration risk of the included research included research and complete data analysis. Results 7 RCT studies were included with a total of 396 adult patients.Among the stuey compared U-LRM with Non-LRM,RCTs showed a significant benefit of U-LRM for reducing the incidence of atelectasis at T3(RR = 0.52;95%CI [0.39, 0.69];P < 0.001;I² = 0%) and the LUS at T3(MD=-3.50; 95%CI[-5.06, -1.94];P < 0.001;I² = 86%).Among the stuey compared U-LRM with LRM, RCTs showed a significant benefit of U-LRM for reducing the incidence of atelectasis at T2(RR = 0.49;95%CI[0.36, 0.68];P < 0.001 I = 0%) and the LUS at T2(MD=-1.50; 95%CI[-2.90, -0.09];P = 0.04;I = 87%)and T3(MD=-1.58;95%CI [-2.68, -0.47];P = 0.005;I = 78%) Conclusion According to the study,ultrasound-guided lung recruitment maneuvers(U-LRM) may have an association with decreasing in the incidence of perioperative atelectasis and lung ultrasound scores. However,the result must be explained cautiously as the total patients is insufficient.