Background:The aim of the study was to compare the therapy of corneal collagen crosslinking (CXL) for central and paracentral keratoconus.Methods:64 eyes of 43 central keratoconus patients whose highest power of the cornea located in the central 3 mm zone and 24 eyes of 16 paracentral keratoconus patients whose highest power located out of the central 3 mm zone received standard corneal CXL were included. Maximum keratometry (Kmax) and astigmatism according to topography, uncorrected distant visual acuity (UDVA), corrected distant visual acuity (CDVA) were studied preoperatively and 2 years postoperatively.Results:Central group: Preoperative UDVA and CDVA were 0.9 ± 0.4 and 0.5 ± 0.4 logMAR, respectively. At 2 years, UDVA and CDVA significantly improved to 0.8 ± 0.4 and 0.4 ± 0.3 logMAR(P < 0.01). Preoperative Kmax and astigmatism were 61.5 ± 14.7 diopter (D) and 4.0 ± 2.9 D, respectively. At 2 years, Kmax and astigmatism significantly decreased to 57.0 ± 10.4 and 3.0 ± 2.2 D (P < 0.01). Paracentral group: preoperative UDVA and CDVA were 0.8 ± 0.7 and 0.2 ± 0.4 logMAR, respectively. At 2 years, UDVA significantly improved to 0.4 ± 0.4 logMAR(P < 0.01), whereas CDVA remained 0.2 ± 0.3 logMAR(P > 0.05). Preoperative Kmax and astigmatism were 50.3 ± 5.3 and 2.4 ± 1.7 D, respectively. At 2 years, Kmax significantly decreased to 48.8 ± 4.6 (P < 0.01), whereas astigmatism remained 2.2 ± 1.8 D (P > 0.05).Conclusion:This study indicated that CXL was more effective for central keratoconus than paracentral keratoconus.

These results show that fLASIK provides better visual quality than OK for patients with low-to-moderate myopia.