A systematic microscopic analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS2 nanoribbon is presented. The variations of the transverse electronic current along the two-dimensional (2D) membrane due to the translocation of DNA and protein molecules through the pore are obtained by model calculations based on molecular dynamics (MD) and Boltzmann transport formalism, which achieved good agreement with the experimental data. Our analysis points to a self-consistent interaction among ions, charge carriers around the pore rim, and biomolecules. It provides a comprehensive understanding of the effects of the electrolyte concentration, pore size, nanoribbon geometry, and also the doping polarity of the nanoribbon on the electrical sensitivity of the nanopore in detecting biomolecules. These results can be utilized for fine-tuning the design parameters in the fabrication of highly sensitive 2D nanopore biosensors.

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Gating in ion transport is at the center of many vital living-substance transmission processes, and understanding how gating works at an atomic level is essential but intricate. However, our understanding and finite experimental findings of subcontinuum ion transport in subnanometer nanopores are still limited, which is out of reach of the classical continuum nanofluidics. Moreover, the influence of ion density on subcontinuum ion transport is poorly understood. Here we report the ion density-dependent dynamic conductance switching process in biomimetic graphene nanopores and explain the phenomenon by a reversible ion absorption mechanism. Our molecular dynamics simulations demonstrate that the cations near the graphene nanopore can interact with the surface charges on the nanopore, thereby realizing the switching of high-and low-conductance states. This work has deepened the understanding of gating in ion transport.

Two color optical pumping, both above (anti-Stokes pump or ASP) and below (Stokes pump) the lasing wavelength, was adopted to reduce the net quantum defect (QD) in a solid-state Yb-doped fiber laser. The reduction in QD was achieved by converting a substantial portion of the gain medium's phonons directly into useful photons through a dual-wavelength excitation (DWE) mechanism. Since this is achieved through the usual processes of absorption and stimulated emission associated with lasing, high efficiency can be maintained. Both time domain and power measurements are presented, demonstrating a 13.2% reduction of the system's net QD and a 13.8% reduction in the lasing threshold power. These values were limited only by the available ASP power. Laser slope efficiency, with respect to launched ASP power, was found to be as high as 38.3%. A finite difference time domain model, developed to elucidate the role of both pumps in populating the upper states, corroborated the experimental findings. The DWE concept proposed here opens the door to an “excitation-balanced” type of self-cooled fiber laser. Simulation results also suggest that the technique is scalable and conceptually applicable to other solid-state laser systems.

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