Isoflavonoids and isoflavonoid glycosides have drawn much attention because of their antioxidant radical-scavenging capacity. Based on computational methods, we now present the antioxidant potential results of genistein (1), biochanin A (2), ambocin (3), and tectorigenin 7-O-[β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside] (4). e optimized structures of the neutral and radical forms have been determined by the DFT-B3LYP method with the 6-311G(d) basis set. From the findings and thermodynamic point of view, the ring B system of isoflavones is considered as an active center in facilitating antioxidant reactions. Antioxidant activities are mostly driven by O-H bond dissociation enthalpy (BDE) following hydrogen atom transfer (HAT) mechanism. Antioxidant ability can be arranged in the following order: compounds (4) > (3) > (2) > (1). Of comprehensive structural analysis, flavonoids with 4′-methylation and 6-methoxylation, especially 7-glycosylation would claim responsibility for antioxidant enhancement.

This study investigates the effects of direct and indirect dispersion methods for lovastatin solid dispersion (LSD) in alginate (AG)/chitosan (CS) composites on the characteristics and properties of the AG/CS/LSD composites. The preparation method significantly influences the structure, morphology, and LSD size distribution of the composites as well as the drug release of LSD from the samples. The differences in dispersion methods for LSD lead to differences in the interaction between the components, the structure, and the control drug release of LSD. Lovastatin was released from the samples containing LSD in two stages (a fast release stage and a slow release stage), and the drug release content prepared using the indirect method is lower than that prepared using the direct method in the same buffer solution. After 32 h of testing, the released LSD content from the indirect and direct LSD dispersion methods in pH 2 and pH 7.4 buffer solutions was 87–94% and 41–61%, respectively. Drug release kinetics from the above samples in solutions with different pH values was also set up.

This article reports the effect of ginsenoside Rb1 on some properties, morphology, and the drug release process of the chitosan (CS)/alginate (AG)/lovastatin (LOV) composite films prepared by a solution method using different contents of ginsenoside Rb1. The ratio of AG/CS was fixed at 4/1 (wt.%/wt.%), the content of LOV was 10 wt.%, and the content of ginsenoside Rb1 was changed from 1 to 5 wt.%. The results of scanning electron microscopy and Fourier transform infrared spectroscopy analysis showed that the composite films have a heterogeneous structure and the ginsenoside Rb1 content influenced on the structure of composite films. The presence of ginsenoside Rb1 did not influence on the melting temperature of these films but caused a significant difference in the melting enthalpy of the films. The ginsenoside Rb1 was also contributed positively on the LOV release from these films in different pH buffer solutions. The LOV release process from these films included two stages (fast/burst release and slow/control release). It was increased remarkably by the synergic effect of LOV and ginsenoside Rb1 in the drug release process. From the obtained results, we suggested that ginsenoside Rb1 plays an important role not only in the enhancement of health and immunity as general but also as an efficient agent in control of the LOV size as well as LOV drug release from the composite films.