A device able to electrokinetically concentrate cationic samples has many potential medical and industrial applications, but until now has remained undeveloped due to the lack of a commercial anion‐permselective material leading to a prohibitively complex fabrication procedure. Herein, a novel multiscale‐porous anion exchange membrane (MP‐AEM) that enables the convenient and scalable electrokinetic concentration of cationic species is proposed. A mechanically enhanced multiscale‐porous structure with a solid framework is realized by adopting polyester resin as an additive to overcome the intrinsic limitations of the AEM material. The scalable MP‐AEM‐embedded electrokinetic concentrator is devised based on the peculiar properties of the MP‐AEM that for allow both ion and fluid transport. With the MP‐AEM, the concentrator is fabricated in a highly streamlined manner consisting only of a simple insertion and assembly. The concentration performance of the MP‐AEM‐embedded electrokinetic concentrator is demonstrated with a positively charged fluorescent dye and a fluorescein‐labeled protein, and the results show enrichment factors of 250 and 500, respectively. The MP‐AEM makes cationic electrokinetic concentration more accessible and scalable, thereby enabling further progress in a wide range of fields.

For microfluidic applications, we propose a nanochannel for easy fabrication and integration, which is capable of an easy transition between the 3 regimes on demand. We demonstrated an ionic diode and pre-concentration/sensing of DNA.