The world is facing a new geopolitical challenge in the pandemic caused by the spread of COVID-19. The world economy has shrunk by about 3%. The trade war between the United States and China and their defensive agreements with other countries was already a huge problem, but it has reached a critical stage due to COVID-19. The United States has filed multiple lawsuits against China, alleging that they purposely released the Coronavirus. The objective of this article is to examine the shifting Geopolitics, focusing on international economic and defensive relationships among countries, and especially on the Second Cold War between the United States and China. In this pandemic situation, more countries are facing economic downturn and loss of human life. A new geopolitical journey has been started, which is based on the availability of Personal Protective Equipment (PPE) and medical products. All previous problems that had not yet been solved by the United Nations have become fresh challenges. Another big challenge is the demise of Neoliberalism in the world. Bureaucratic wars have started in the interregional and intraregional zones, and the Second Cold War has started between the United States and China. A major finding of this article is the significant correlation between the death rate of different countries and the shift of geopolitics to a critical stage.