Background The objective of this study was to identify the most frequent type, nature, and cause of work‐related injuries among distillery workers and the contributing factors for these events to target interventions to reduce injuries. Methods Workers′ compensation first reports of injury (FROI) from the years 2010 through 2019 were obtained. Variables were created for “occupational category” and “cause of injury” for evaluation of the injurious events. The ratchet circular scan test was used to assess seasonal variation in injury, and kernel density estimation to assess rates of injury by calendar year. Results A total of 974 FROIs were recorded over these 10 years; 908 of the injuries resulted in lost time, 65 resulted in no lost time, and 1 resulted in a fatality. The most common injuries reported were strains or tears, lacerations, and contusions (33.4%, 14.7%, and 13.5%, respectively). The most frequent anatomical sites of injury were the shoulders, fingers, and low back area (11.8%, 11.4%, and 8.9%, respectively). Barreling operation activities experienced the greatest frequency of work‐related injury at 28.5% of all FROIs. A seasonal peak of injuries was observed during May and June. Conclusions Implementing ergonomic and safety solutions for transportation and work tasks associated with barreling operations may significantly reduce the rate of work‐related injuries in distillery workers. Injury prevention interventions should particularly target strain or tear injuries caused by repetitive motion or bodily reaction and overexertion. Contact with objects or machinery accounted for one‐third of distillery industry FROIs.