Background: Diabetes mellitus is characterized by inability of the body to metabolize glucose properly. The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. IDDM and NIDDM shows effect on central nervous system, peripheral nervous system, autonomic nervous system, cardiovascular system and other physiological system. A common complication due to the IDDM and NIDDM includes peripheral neuropathy, retinopathy, nephropathy and vascular complication. Insulin and non-insulin dependent diabetes mellitus -both affect the peripheral nervous system depending on the duration of exposure and blood glucose level.Materials and Methods: 120 healthy individuals with IDDM and NIDDM were included (screened with SF-36), with age limit between 25 to 60 years. Those individuals having a history of hospitalization in last 1 year, acute fever, present history of radiculopathy and open wound were excluded. Nerve conduction studies of common peroneal, tibial and sural nerves were examined in both groups. Distal Latency, NCV and CMAP/SNAP were taken as outcome measures.Result and Discussion: Bio-statistical analysis has been done using Mann-Whitney test. Result suggest that long duration of exposure has significant (p<0.05) effect on Neurophysiological changes compare to short duration of exposure in IDDM and NIDDM. With longer exposure of diabetes, there is increase in latency, decrease in amplitude and NCV.Conclusion: Long duration of exposure shows significant Neurophysiological changes compare to short duration of exposure in IDDM and NIDDM.

Background: Diabetes mellitus is a disease caused by an inability of the body to metabolize glucose properly. The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. As Insulin and non-insulin dependent diabetes shows their effects on various physiological systems includes central, peripheral and autonomic nervous systems, musculoskeletal, cardiovascular and other vital systems. A common complications due to the IDDM and NIDDM includes peripheral neuropathy, retinopathy, nephropathy and vascular complication. Insulin and non-insulin dependent diabetes mellitus, both affect the peripheral nervous system significantly. Therefore we would like to find out neurophysiological changes on peripheral nervous systems between insulin and non-insulin dependent diabetes mellitus.Aim: To find out the Neuro-physiological changes between IDDM and NIDDM.Materials and Method: 120 individuals screened with SF36 (general health good and above) were included with age limit between 25 to 60 years. Those individuals having a history of hospitalization in last 1 year, acute fever, present history of radiculopathy and open wound were excluded. They were divided into 2 groups IDDM and NIDDM. For nerve conduction study-distal latency, amplitude and NCV of sensory and motor nerves were performed. Nerve conduction studies of common peroneal, tibial and sural nerves were examined in both groups. Latency, NCV and CMAP/SNAP were taken as outcome measures.Result and Discussion: Bio-statistical analysis has been done using Mann-Whitney test. Result suggest that there is a significant difference in Neurophysiological changes (p<0.05) between IDDM and NIDDM groups. Conclusion: In context to our study and neurophysiological findings, individuals with IDDM must be taken into consideration for promotion, prevention, and care as compared to NIDDM for secondary complications.