The purpose of this chapter is to review a holistic approach to the integration of digital portfolios (“ePortfolios”) as an instructional method in online degree programs. The chapter reviews the evidence-based best practices that support four phases to the integration of ePortfolios as an instructional method in online degree programs: scaffolding, tutorials, course integration, and student engagement. Each phase offers a different way to make a lasting impact on students. The innovative instructional method is not the portfolio itself, the supporting tutorials, or any one piece of the ePortfolio project. Rather, the true innovation is the project as a whole, taking a holistic look at how portfolios fit into the program and how to support the development and evaluation of the portfolio for both students and faculty.