Objective: To investigate the clinical validity of the mathematical measured VVOR test results to detect horizontal semicircular canal hypofunction. Study Design: Prospective, nonrandomized, observational study. Setting: Tertiary referral center, hospital. Patients: Consecutive patients on first time visit to otoneurology unit. Intervention(s): Diagnostic. Main Outcome Measure(s): Values of statistical indicators of clinical validity for VVOR test to detect horizontal canal hypofunction were used considering vHIT horizontal aVOR gain values as gold standard. Results: Area under curve of ROC curve for quantified VVOR testing was 0.92. Head movement frequency on VVOR test and contralateral VVOR gain were identified as significant influence factors of (unilateral) VVOR gain (p < 0.0001) on statistical linear model. Conclusions: According to the obtained results, the quantified VVOR test has excellent clinical validity for detecting angular horizontal VOR hypofunction.

The diffusion-weighted magnetic resonance imaging is a very useful technique during the diagnostic process of doubtful cases of cholesteatoma, especially in cases of follow-up. As for the influence of the learning curve, we observed a clear improvement in the specificity of the test.

Objective: To measure and analyze the clinical and epidemiological characteristics of patients and healthy controls with enhanced eye velocity responses as well as evaluate their relationship with endolymphatic hydrops related diseases. Study Design: Cross-sectional clinical study. Setting: Tertiary hospital. Participants: Three hundred sixty three participants allocated to patients (310) and healthy control (53) groups were collected on first time visit to neurotology unit. Intervention: Diagnostic. Main Outcome Measures: Video head impulse test records, clinical diagnose, and variables and demographic data were used to get cross tables, a general linear model, diagnostic epidemiological parameters, and machine learning variable importance evaluation methods. Results: All the statistical tests revealed a significant association between enhanced vestibulo-ocular reflex (VOR) and diagnostic categories ( p < 0.001). Chi-squared residual and machine learning analyses showed Menie `re's disease as the main associated diagnostic category, whereas the lowest residuals and gain values were found in the control group. Enhanced VOR as a diagnostic sign of Menie `re's disease had a sensitivity of 42.59% and a specificity of 86.32%, with an odds ratio of 4.68 ( p < 0.001). Conclusion: There is a significantly higher prevalence of enhanced VOR responses in patients with Menie `re's disease, central origin vertigo, otosclerosis, and vestibular migraine than in those with other neurotologic diseases and controls. Our study found that enhanced VOR are not pathognomonic of hydrops-related diseases and the diagnosis should not solely be based on these and instead take into context other clinical and examination findings.

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