The decision of the Cuban Government to massively introduce Renewable Energy Sources (RES) as a way to change the energy matrix, and in particular, the electricity matrix, is presented as an opportunity to introduce not only sources of energy friendly with the environment, but also make the contributions that, without limiting the development of the country, respond to the UN Millennium Development Goals (UNMDG). However, the large-scale use of RESs in an electrical system such as Cuba, isolated and not interconnected to other systems, can have a group of challenges that must be taken into consideration when it is exploited, since it does not incorporate only new technologies, some of which depend on weather conditions such as solar, wind and hydro technology for the production of electricity, but allow us to think about the introduction of emerging technologies that can increase the penetration of RES in the electrical system and introduce new management concepts, both territorially and nationally. The present work reflects on this, from some experiences that have been analyzed in different research works carried out at CIPEL, plus other international experiences.