No abstract

Riboflavin/UVA collagen cross-linking appears to be efficacious in inhibiting the progression of keratoconus by reducing the corneal curvature, spherical equivalent refraction, and refractive cylinder in eyes with progressive keratoconus at average 9-month follow-up.

PURPOSE:To compare 2 sequences of combined intrastromal corneal ring segment (ICRS) implantation and ultraviolet/riboflavin-mediated corneal collagen crosslinking (CXL) in progressive keratoconus.SETTING: Dunya Eye Hospital, Istanbul, Turkey. METHODS:In this prospective comparative randomized consecutive study, CXL was followed by ICRS implantation (Group 1) or ICRS implantation was followed by CXL (Group 2). Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, spherical equivalent (SE), manifest cylinder (cylinder), and mean keratometry (K) were compared preoperatively and postoperatively. RESULTS:The mean interval between treatments was 7 months G 2 (SD) (mean follow-up, 13 G 1 months). The mean UDVA and CDVA improved in both groups (UDVA: 0.07 G 0.09 to 0.25 G 0.12, Group 1, and 0.11 G 0.09 to 0.32 G 0.21, Group 2; CDVA: 0.24 G 0.11 to 0.41 G 0.20 and 0.22 G 0.16 to 0.55 G 0.2, respectively). The mean SE, cylinder, and mean K values decreased in both groups (SE: À7.13 G 3.34 D to À2.98 G 2.33 D, Group 1, and À7.05 G 5.54 D to À2