The normal placentas, regular pregnancies and deliveries were structurally examined. The aim of this research was to compare the results and to confirm if there were some difference in the structure of placenta related to the age of pregnant women. We examined 30 human placentas. The examined group of women were divided into two groups: 1) pregnant women 20-35 years old; 2) pregnant women over 35 years old. The stereological method was used. The volume density, absolute volume, the surface density and absolute surface of terminal villi of placentas in younger and older pregnant women were not significantly different. The volume density, absolute volume, the surface density and absolute surface of the other placentas villi in younger pregnant women compared to older ones, were significantly increased (p<0.001). The volume density of fibrinoid of placentas in older pregnant women compared to younger ones was significantly increased (p<0.02). The surface density, absolute volume and absolute surface of fibrinoid in these two examined groups of pregnant women were not significantly different. The volume density of intervillous space of placentas in older pregnant women compared to younger ones was significantly increased (p<0.05). Absolute volumes of intervillous space of placentas in these two examined groups of pregnant women are not significantly different.

Introduction: Data on post-COVID-19 in renal transplant recipients (RTR) is scarce.We investigated the rate of hospitalizations, reasons for hospital admission, and mortality rate among RTR who survived acute COVID-19.Methods: A multi-center retrospective observational cohort study measured hospital admission and death to 180 days after acute SARS-CoV-2 infection in 308 adult patients. Results:The median age was 57 years, 64.9% were male. All patients had at least one comorbidity, and 26.3% had diabetes. Data on post-COVID-19 course was available for 267 patients, and 49 of them (15.9%) required hospital treatment after recovery from the acute infection. The most common indications included pneumonia (24.5%) and renal allograft dysfunction (22.4%), 7 (14.3%) had sepsis and 5 (10.2%) had thrombotic events. A median duration of the hospital stay was 12 days. Six patients (2.2%) died due to multiorgan failure, respiratory insufficiency or urosepsis. The strongest predictor for hospitalization after acute COVID-19 was hospitalization for acute SARS-CoV-2 infection, while better allograft function decreased the probability of hospitalization. Conclusion:Delayed consequences of acute COVID-19 are highly prevalent and the health care systems should be prepared to respond to the needs of RTR suffering from post-COVID-19 complications.

Objective: To assess if the patients with pre hCG high perifollicular PSV values, would benefit with a double IUI, instead of single IUI. Method: A randomized prospective study was done of 350 IUI cycles who were stimulated by either CC or rFSH (recombinant FSH) or Letrozole with rFSH and showed a pre hCG perifolliclular PSV of 15cms/sec. Single IUI was done at 36 -38 hours after hCG injection and in double IUI cases the IUI were done at 12-14 hours and 36-38 hours. Results: With CC stimulated cycles when perifollicular PSV was 15-20, single IUI gave nearly similar conception rates with both single and double IUI. With PSV 20 -25 cms/sec, double IUI showed higher conception rates than single IUI. But when was PSV > 25, conception rates were very low with single IUI than with double IUI. With rFSH cycles with PSV 15-20, conception rates were comparable with both single IUI and double IUI but with PSV > 20, the conception rates were significantly better and with PSV > 25, the pregnancy rates with single IUI were significantly low. Same was the case with letrozole + rFSH cycles. Conclusion: In all cases with PSV > 25 cms/sec on the day of hCG, a double IUI gives better pregnancy rates, but this limit lowers to PSV 20, when it is a rFSH cycle. P20.13Estimation of uterine cavity codition by three-dimensional hysterosonosalpingograpy Background: Congenital and acquired uterine anomalies are relatively often and correlate with infertility and habitual abortions. Objective: To estimate sensitivity and specificity of three-dimensional hysterosonosalpingography (3D HSSG) compared to hysteroscopy. Methods: 60 patients, divided into two groups, were included in this prospective study. In the first group, which consisted of 30 patients, estimates were done by 3D HSSG with negative contrast, and compared to findings of hysteroscopy done on the same patients. The second group, which also consisted of 30 patients, had uterine cavity estimation done by 3D HSSG with hyperechogenic contrast, and compared to finding of hysteroscopy done on these 30 women. Results: Sensitivity and specificity of 3D HSSG with negative contrast was 100% compared to hysteroscopy. Sensitivity of 3D HSSG with hyperechogenic contrast compared to hysteroscopy was 66.6% for synechiae, 94.7% for septum and 100% for other uterine anomalies, while specificity was 100% for all uterine malformations. Conclusion: Results of this study show that 3D HSSG with negative contrast is the best method for uterine cavity vizualisation, and estimation, and it presents precise and minimally invasive alternative, that provides this method to be used in routine ambulatory practice.