In this study, in vitro and in vivo experiments, it was studied soforaflavonozide (SFL) isolated from Alhagi canescens (Regel) B. Keller & Shap (Fabaceae (Leguminosae)), and narcissine isolated from Crocus sativus L. belonging to Iridaceae family. It was studied the effect of narcissine isolated from the plant on ATP-dependent potassium channel (mitoK ATP -channel) activity in rat cardiac mitochondria. Animals of experimental group were divided into 4 groups: I control group (healthy), II experimental group (ischemia model), III experiment group (ischemia + narcissin), IV experimental group (ischemia + SFL). In rats with ischemia a 0.1 ml 0.1% solution of 100 mg/kg adrenaline was administered subcutaneously and peritoneally for 3 days in relative to body weight. The rats that underwent the ischemia model were given oral administration of 10 mg/kg of narcissine flavonoid to group III and 10 mg/kg of SFL flavonoid to group IV orally for 7 days. After that, in the experimental animals carried out electrocardiogram. Mitochondria from rat heart tissue were isolated by differential centrifugation. Cardiac mitoK ATP -channel activity in the presence of ATP in an incubation medium was studied at concentrations of 10-50 µM of SFL and narcissine. Concentrations of 50 µM of SFL and narcissus and 30 µM of diazoxide were also found to have an activating effect on the mitochondrial channel of the heart. In the adrenaline-induced ischemia model, it was found that narcissine and SFL flavonoids restored the mitochondrial conduction permeability of the rat heart.