Introduction: Hepatitis A is one of the most frequent infectious liver diseases affecting children worldwide. The disease is usually mild and self-limited, and complications are very rare. But sometimes hepatitis A can cause acute liver failure (ALF), a severe, life-threatening condition. The objective was to do clinicoepidemiological evaluation of hepatitis A patients who were admitted to the In patients department of our hospital along with analyze the complications seen in the disease.Materials and Methods: It was a prospective study, done in Department of paediatrics, Maharaja Krushna Chandra Gajapati from May 2014-April 2016. Total number of patients was 80. Patients having history or features of prodromal symptoms like fever, nausea, vomiting, anorexia, yellowish discoloration of urine and body, pain abdomen, change in mental status and coagulopathy with suspicion of acute hepatitis (within 8 wks) with positive IgM for hepatitis A were included in the group. Statistical analysis was done by SPSS software version 20.Results: Total number of patients was 80. Mean age of hospitalisation was 5.5 years. 90% children were having jaundice. 85% patients were having liver enzyme high. Most common complication was gallbladder wall thickening followed by ascitis, pleural effusion etc. Encephalopathy was observed in three patients. Total three patients died. Maximum death was seen in infancy with delay in hospitalisation.Conclusions: Viral hepatitis due to hepatitis A is a benign disease. But fulminant hepatic failure due to it is not uncommon. The lesser the age, presence of cardinal features like jaundice may not be apparent. So clinicians must be conscious of these lethal complications while managing a child of probable viral hepatitis. This study will raise the consciousness of urgency of vaccination for hepatitis A, which is thought to be sparingly optional for many parents as well as doctors.

Introduction: Idiopathic inflammatory demyelinating disorders of the central nervous system (IIDCDs) represent a broad spectrum of central nervous system (CNS) disorders thought to be of autoimmune origin. Objective of the study was to diagnose multiple sclerosis by neurological examinations, to do neuroimaging and to see the most common area of involvement. Materials and Methods: Prospective clinical study in

Background: Skin lesions are much common and specific to neonates. They vary according to age, sex, and geographic region. Objectives: The objective of this study was to determine the prevalence of different cutaneous lesions in newborns and their association with the type of delivery, age, sex, and maturity. Materials and Methods: This study was done in neonatal follow-up clinic of department of Pediatrics, Maharaja Krushna Chandra Gajapati Medical College, Berhampur, Odisha. All the healthy newborns coming to the OPD from January 2015 to December 2016 were included in this prospective study, and their details were recorded in case recording format after taking informed consent from their guardians. Admitted patients were excluded from the study. Statistical assessments were the done by SPSS software. Results: Out of 500 neonates, skin lesionswere found in 366 (73.2%) patients. Physiological cutaneous lesions were most common, consisting 259 (70.7%) neonates. Out of the physiological lesions, benign transient lesions were seen in 163 (44.6%), out of which 95 (25.9%) had papulopustular dermatoses followed by erythema toxicum in 48 (13.1%) cases. Birthmarks were seen in 138 (37.8%) cases; pigmentary birthmarks 89 (24.5%) being the most common birthmarks followed by Mongolian spots in 71 (19.4%) cases. Pathological lesions were seen in 107 (29.3%) cases, of which nappy rash was detected in 65 (18.01%) cases. Term and male babies had a higher incidence of skin lesions. Conclusion: Benign lesions are the most common group of neonatal cutaneous manifestations which is followed by birthmarks. Conditions such as nappy rash and contact dermatitis are common pathological lesions andmajority of them are preventable. Differentiation of the physiologic skin lesions from the pathologic ones is essential to avoid unnecessary therapeutic interventions.