Inflammation is still a major factor in the majority of diseases and physiological imbalances. Acute inflammation is a protective mechanism used by the immune system to remove the source of inflammation, and failure to resolve it leads to chronic inflammation. In other words, inflammation is a cleansing process that helps to maintain homeostasis by removing invading materials and noxious alterations. Serratiopeptidase, a proteolytic enzyme from the trypsin family, has a wide range of applications in the fight against inflammation. Nonsteroidal anti-inflammatory medicines (NSAIDs) are the most commonly used treatments to treat acute inflammation, either alone or in combination with other medications. These medications have a number of drawbacks, including side effects, adverse drug reactions, and so on. Enzyme-based anti-inflammatory medications have become more popular than chemical-based anti-inflammatory drugs as a result of these limitations and consequences

The goal of the Novel Drug Delivery System is to deliver a therapeutic dose of drug to an appropriate place within the body quickly so that the desired drug concentration can be maintained. Over a set treatment period, the drug-delivery system should supply the medicine at a rate controlled by the body's requirements. A transdermal patch is a medicated adhesive patch that is applied to the skin to deliver a specific amount of medication into the bloodstream through the skin. This generally aids in the recovery of a damaged bodily part. The patch provides a controlled release of medication into the patient, usually through a porous membrane covering a reservoir of medication or through thermoregulation melting thin layers of drug incorporated in the adhesive, which is a benefit of transdermal drug delivery over other types of medication delivery such as oral, topical, intravenous, intramuscular, and so on. As a result of persistent experimentation with nature, man must have known the therapeutic potential of neem since past. When used both internally and externally, it is beneficial to the skin. It cleanses the blood and treats acne, pimples, boils, and other skin problems. The flavour of neem is bitter. However, it is this bitterness that is responsible for the tree's therapeutic efficiency. Transdermal patches are presently available in a wide range of therapeutics.

Nutraceuticals are the products derive from food sources with extra health benefits. They can prevent malignant processes. The term ‘nutraceuticals’ combines two words ‘nutrients ( a nourishing food component ) and ‘pharmaceuticals’(a medical drug ) The philosophy behind nutraceuticals is according to Hippocrates “ Let food be your medicine”. Categories of nutraceuticals are dietary supplements, functional food, medicinal food, pharmaceuticals. Advance age is often characterized by a declined in large spectrum of cognitive abilities including reasoning, memory, perceptual speed and language. Alzheimer’s disease (AD) is the most common and feared from dementia representing circa 70% of all dementia cases and displaying a dramatic epidemics due to the enormous growth of the aged population worldwide. It is still unclear which factors lead to molecular cascade of neurode generation in AD, but along with genetic environmental factors vascular pathology and risk factor have been recently shown to play crucial role in AD pathogenesis .AD impacts dramatically on everyday life of older adults, being one of the main cause of disability in old age. There is clear evidence that a diet rich in specific nutritional food group (fruit, fish, vegetables) can reduce the incidence and prevalence of some of the main clinical outcomes, such as neurodegenerative disorders, cardiovascular diseases, diabetes, cancer. This specific nutritional food group are rich in micronutrients and vitamins are beneficial for health. The Mediterranean diet is characterized by a high consumption of plant food, fish olive oil as primary source of monounsaturated fat and moderate intake of wine. In this article, we focus our attention on group of substance proposed to prevent or treat Alzheimer’s disease.