Immune-related cutaneous events can develop after immunotherapy. To our knowledge, we present the first reported case of isolated focal penile inflammatory ulceration in a patient being treated with Nivolumab for stage IV non-small cell lung carcinoma. He presented with a painless penile ulceration two months after initiating therapy. He had near-complete resolution of his ulcer after two weeks of topical treatment. Histologic evaluation revealed a drug eruption. While cutaneous events are a well-known side effect of immunotherapy, this is the first report of an isolated penile lesion from such therapy.
Background/study aims
Angioimmunoblastic T‐cell Lymphoma (AITL) is a rare T‐cell lymphoma often presenting with constitutional symptoms and lymphadenopathy. It can have an association with Epstein‐Barr Virus (EBV) infection and auto‐immune phenomena such as haemolytic anaemia. This case details a Gastric Mass as the initial findings of AITL, a rare occurrence.
Patients and methods
Case report detailing a 64‐year‐old female presenting with a suspicious gastric mass and auto‐immune haemolytic anaemia. Hospital workup was notable for serology consistent with acute EBV infection and positive anti‐smooth muscle antibody. Tissue biopsy and lymph node resection yielded histologic diagnosis of AITL.
Results
Once the patient was diagnosed with AITL, they were placed on Gemcitabine, Cisplatin, Prednisone and Thalidomide with subsequent improvement in haemolytic anaemia and gastric mass size.
Conclusions
This case demonstrates a unique presentation of Angioimmunoblastic T‐cell Lymphoma in the context of a Gastric Mass and associated Auto‐immune Haemolytic Anaemia. This case also continues to show evidence of a strong relationship between Epstein‐Barr Virus and Angioimmunoblastic T‐cell Lymphoma.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.