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The comparative study was aimed to evaluate the potential anticancerous and cardioprotective activities of methanolic leaf extract of Cycleabarbata and Entadapursaetha. The screening of anticancerous activity was performed using brine shrimp lethality bioassay while the cardioprotective activity was evaluated using the in vitro clot lysis model. Significant anticancerous activity was found for methanolic leaf extract of C. barbata whereas moderate effect was found for methanolic leaf extract of E. pursaetha and it was compared with the standard drug vincristine sulfate in the brine shrimp lethality bioassay. In the present study, the LC 50 values of methanolic crude extract of C. barbata, E. pursaetha and vincristine sulfate were 104.04, 330.31 and 12.59 μg mLG 1 , respectively. In cardioprotective study, it was found that C. barbata and E. pursaetha showed 45.69±1.96 and 38.19±1.83% of clot lysis, respectively. Between the plants studied C. barbata, showed very significant (p<0.05) percentage of clot lysis than E. pursaetha compared to reference drug streptokinase which is 63.54±2.61%. The results of this study demonstrated that the leaf of these plants possess promising anticancerous activity on brine shrimp as well as significant cardioprotective activity in vitro when tested on human blood.

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