A motor system configured to maximize the stability of its current state cannot dexterously transition between states. Yet, we routinely resolve the stability-dexterity conflict and rapidly change our current behavior without allowing it to become unstable before the desired transition. The phenomenon called anticipatory synergy adjustment (ASA) partly describes how the central nervous system handles this conflict. ASA is a continuous decrease in the stability of the current motor state beginning 150-400 ms before a rapid state transition accomplished using redundant sets of motor inputs (more input variables than task-specific output variables). So far, ASAs have been observed only when the timing of the upcoming transition is known. We utilized a multifinger, isometric force-production task to demonstrate that compared with a condition where no state transition is expected, the stability of the current state is lower by ~12% when a participant is cued to make a transition, even when the nature and timing of that transition are unknown. This result (stage 1 ASA) is distinct from its traditional version (stage 2 ASA), and it describes early destabilization that occurs solely in response to the expectation to move. Stage 2 ASA occurs later, only if the timing of the transition is known sufficiently in advance. Stage 1 ASA lasts much longer (~1.5 s) and may scale in response to the perceived difficulty of the upcoming task. Therefore, this work reveals a much refined view of the processes that underlie the resolution of the stability-dexterity conflict. NEW & NOTEWORTHY We compared the stability of multifinger, isometric force-production tasks for trials in which force changes of unknown direction and timing were expected with trials in which there was no expectation of any force change. Mere expectation of a change caused the stability of the current motor state to drop. This novel result provides a much refined view of the processes that facilitate dexterous switching between motor states.

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The authors examined how the stability of the current total isometric force (FT) produced by four fingers is influenced by previous and expected voluntary changes in FT. The authors employed the synergy index obtained from the across-trial uncontrolled manifold analysis to quantify the stability of FT. The authors compared two tasks with similar histories of FT changes; one in which participants expected changes in FT in the future, and one in which they expected no changes in FT. The stability of FT was lower in the former task, indicating the existence of a novel type of anticipatory synergy adjustment. Disparate histories of FT changes yield inconsistent changes in stability, driven by individual differences in the covariation in the finger forces that leave FT invariant. Future research should focus on exploring these individual differences to better understand how previous and expected behavior changes influence the stability of the current motor behavior.

Anticipatory synergy adjustment (ASA) is a feed-forward control mechanism that describes a continuous decrease in the stability of the current motor state beginning about 150 ms prior to a state transition. Recently, we described an associated phenomenon in which the system stability was reduced solely in response to a cue that generates an expectation of a state change, independent of whether the state change actually occurs. Both phenomena are of the same kind (stability reduction), but evoked by distinct antecedent conditions. Since, logically, cuing for movement must occur before the initiation of that movement, we named this new phenomenon 'Stage-1 ASA' and rechristened the well-established version 'Stage-2 ASA'. Here, we used a four-finger, isometric force production task to explore (1) the effect of healthy aging on Stage-1 ASA, and (2) if Stage-1 ASA resulted in a more rapid state change. Young and older adult participants produced 10% of their maximal force when they did not expect to produce any change in the force, and when they expected to change their force in an unknown direction and at an unknown time. In the latter condition, the 10% constant-force phase was followed by a choice reaction time task, in which the participants rapidly changed their force to follow a moving target presented on a computer monitor. Both young and older adults displayed equivalent amount of Stage-1 ASA. This was driven by a 42% reduction in finger-force variability in young adults. In contrast, it was driven by a 38% increase in finger-force variability in older adults. We speculate that the reduction in finger force variability assists the young adults in rapid state changes via two mechanisms: (1) the finger forces occupy a restricted set of states that are optimal for quick state transitions, and (2) lower variability during steady state translates into lower self-motion during state transition. Self-motion is the covariation between finger forces that fails to change the total force. The older adults are unable to adopt this strategy, and the increase in finger-force variability arises from (1) the adoption of an alternative strategy of destabilizing the attractor associated with the current state to facilitate state transitions and (2) the inability to coordinate multiple finger forces. Finally, older adults displayed longer reaction times than young adults, but a clear relation between Stage-1 ASA and consequent behavioral benefit in terms of reduced reaction time remained elusive.

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