A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl) hexahydro-1,3,5-triazine derivatives (3) have been synthesized by condensation of substituted benzothiazoles with 2,4,6-trisubstituted 1,3,5-trioxane by conventional as well as microwave irradiation (solvent free and solid support) methods. All compounds were tested for antiproliferative activity and entomological activity. The microwave irradiation technique gives better yield and reaction completion in a shorter period of time. Among solid supported microwave irradiation better yields are obtained with acidic alumina as compared to silica, neutral alumina and basic alumina.The results of biological activities prompted us that change in substitution pattern in benzothiazolyltriazine derivatives may cause marked effect on their antiproliferative activity.

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2-Amino-6-substituted-1,3-benzothiazoles were condensed with N,N-dimethylaminobenzaldehyde to give novel 2-(4 0 -N,N-dimethylbenzylidenoimino)-6-substituted-1,3-benzothiazoles in good yields. However, in the case of 2-amino-6nitro-1,3-benzothiazole, the desired product 2-(4 0 -N,N-dimethylbenzylidenoimino)-6-nitro-1,3-benzothiazole was not observed. Products were characterized by elemental analysis and infrared (IR) and 1 H NMR spectroscopy. Two crystal structures were determined. ClC 6 H 3 (SCN)N¼ ¼CHC 6 H 4 N(CH 3 ) 2 crystallizes as triclinic,

Abstract:A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-methylbenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield and shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and antifungal activities and results have been compared with standard drugs. Entomological activities were also tested. The results showed that a change in the substitution pattern in 1,4-dihydropyridine derivatives may cause a marked effect on their antimicrobial activity.