ABSTRACT.Purpose: To study changes in the oxygen saturation and calibre of retinal vessels in the eyes of patients with retinitis pigmentosa (RP). Method: In this cross-sectional study, 63 eyes of 63 patients with RP and 14 eyes of 14 healthy subjects were enrolled and examined at Toyama University Hospital. Retinal oximetry measurements were performed using a spectrophotometric oximetry unit (Oxymap T1, Reykjavik, Iceland), which is coupled to a fundus camera base (TRC-50DX; Topcon Corporation, Tokyo, Japan). Retinal arterioles of 28 eyes and retinal venules of 35 eyes with adequate image quality were selected for analyses. We calculated the residual areas of visual field (I-4e and V-4e isopters) in each eye and determined the correlations between the data of retinal vessels and the areas of visual field in the RP eyes. Results: The mean oxygen saturation of the venules in the RP eyes (60.2 AE 6.5%) was significantly higher than that in healthy eyes (54.6 AE 6.3%, p = 0.0089). The oxygen saturation of the venules in the RP eyes correlated significantly with the residual areas of the visual field of V-4e (r = À0.50; p = 0.0030). The mean calibres of the retinal arterioles (91.1 AE 9.1 lm) and retinal venules (116 AE 13 lm) of the RP eyes were significantly narrower than those of the healthy eyes (115 AE 11 lm and 152 AE 15 lm, respectively, p < 0.01). The retinal arteriolar and venular calibres in the RP eyes correlated with the residual areas of the visual field of V-4e (r = 0.43; p = 0.033 and r = 0.45; p = 0.011, respectively). Conclusions: The severity of RP was correlated with increased oxygen saturations in the retinal venules and decreased retinal vessel calibres.

Purpose. To evaluate the efficacy of setting a preferred retinal locus relocation target (PRT) and performing Macular Integrity Assessment (MAIA) biofeedback training in patients showing insufficient recovery of best corrected visual acuity (BCVA) despite successful closure of an idiopathic macular hole (MH). Methods. Retrospective interventional case series. Nine eyes of 9 consecutive patients with the decimal BCVA of less than 0.6 at more than 3 months after successful MH surgery were included. A PRT was chosen based on MAIA microperimetry and the patients underwent MAIA biofeedback training. BCVA, reading speed, fixation stability, and 63% bivariate contour ellipse area (BCEA) were evaluated before and after the training. Statistical analysis was carried out using paired Student's t-test. Results. PRT was chosen on the nasal side of the closed MH fovea in 8 patients. After the MAIA training, BCVA improved in all patients. The mean logMAR value of BCVA significantly improved from 0.33 to 0.12 (p = 0.007). Reading speed improved in all patients (p = 0.29), fixation stability improved in 5 patients (p = 0.70), and 63% BCEA improved in 7 patients (p = 0.21), although these improvements were not statistically significant. Conclusion. MAIA biofeedback training improved visual acuity in patients with insufficient recovery of BCVA after successful MH surgery.

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The IOP fluctuation was larger in the eyes with PE than in the healthy eyes. This larger fluctuation might be one of the reasons underlying the aggravation of the visual field by PE. Measurements of 24-hour continuous IOP might be useful to evaluate IOP fluctuation.

Cataract surgery decreased IOP fluctuations during the nocturnal period in PACG patients. These effects might partly prevent the progression of PACG.