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Post-traumatic postoperative osteolysis is a rare cause of recrudescence of osteolysis in previously quiescent sclerotic pagetic bone. This condition can develop rapidly following trauma and operation, and mimic sinister causes like malignancy. Awareness of this rare disease entity can help in prompt diagnosis and treatment for reversal of osteolysis. Here we report on a middle-aged man who developed post-traumatic postoperative osteolysis over the pagetic humerus after internal fixation for pathological fracture. To the best of our knowledge, this is the first reported case for this condition to occur in the humerus.

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