Circulating oxidised LDL (ox-LDL) is associated with obesity, insulin resistance (HOMA), metabolic syndrome, and cardiovascular disease in adults. Little is known about relations in children. Aim To assess association of ox-LDL with fat distribution and insulin resistance in a group of obese Egyptian children. Methods Study is cross-sectional consisted of 68 obese children, mean age 9.96 ± 1.32. Each underwent a complete physical examination; blood pressure (SBP, DBP) and anthropometric measurements (weight, height, BMI; waist, hip circumferences, waist/hip ratio), biochemical tests of fasting blood glucose (FBS), insulin levels; lipid profile (TC, LDL, HDL, TG) and ox-LDL; calculated HOMA. Sample was classified according to waist/hip ratio into: group I with and groupII without central obesity. Results ox-LDL showed significant positive correlation with LDL and TC in all groups of obesity. After adjustment for age and sex, significant positive correlation was detected between ox-LDL with SBP, DBP, TC, LDL, insulin, and HOMA in groupII and with TC and FBS in groupI. Insignificant association was detected between ox-LDL and other anthropometric parameters including BMI in any group of obese children (p > 0.05). Conclusions ox-LDL, as a marker of oxidative stress is not correlated with BMI among all studied obese children (aged 6–12 years). Increased oxidative stress has causal effects on insulin resistance in obese children without central obesity and on fasting blood sugar in those with central obesity. These findings emphasise the importance of obesity during childhood and suggest that the metabolic complications of obesity and body fat distribution are detectable early in life.

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Results MS cases showed a higher distribution of TG and GG genotypes compared with cases without MS. Carriers of the mutated genotypes (TG+GG) exhibited higher levels of body mass index, body fat percentage, blood pressure, fasting insulin, fasting glucose, HOMA-IR, triglyceride, whereas lower levels of HDL-C and serum concentrations of adiponectin as compared with TT carriers. Association between MS and mutated genotypes of ADIPOQ gene 45T > G was observed (adjusted odds ratios (OR) = 3.65 for TG+GG carriers, OR = 2.25 for GG carriers and OR = 1.9 for G allele carriers). Conclusions The study suggests that adiponectin 45T > G polymorphism has a significant role in the development of MS in Egyptian female adolescents, possibly through an interaction with increase body weight and hypoadiponectinemia. Background The correlation between body composition changes, osteopenia and alterations of leptin, Insulin-like-Growth Factor-1(IGF-1) and cortisol levels has been previously found in patients with anorexia nervosa (AN). Objective The aim of this study was to investigate the relationship between bone formation (osteocalcin-OC) and bone resorption markers (BetaCrossLaps-BCL) and changes in bone mineral density (BMD), body mass index (BMI), body fat percentage (BF %), leptin, IGF-1 and cortisol levels. Methods BMI, spinal Z-score (DXA), BF% and leptin, IGF-1, OC, BCL, cortisol levels were measured in 2 groups of girls: AN (n = 20, age 17.2 ± 0.3 years, amenorrhea duration 21.2 ± 0.4 months) and normal weight (n = 20, age 17.5 ± 0.2 years). Results BMI (14.2 ± 0.86 vs 20.4 ± 0.86, t = -22.77, p = 0.0009), BF%(5.0 ± 1.5 vs 22.9 ± 2.7, t = -25.79, p = 0.0001), Z score (10.5 vs 30.5, Z = -5.41, p = 0.0006) and levels of IGF-1(308.1 ± 42.6 vs 538 ± 21.6; t = -9.75, p = 0.0007), leptin (10.5 vs 30.5, Z = -5.41, p = 0.0006) and OC (16.0 ± 3.49 vs 37.2 ± 5.34, t = -14.84, p = 0.0002) were significantly lower in AN group while levels of cortisol (713 ± 69.1 vs 451 ± 15.9; t = 11.82, p = 0.0003) and BCL (28.1 vs 12.9, Z = -4.1, p = 0.0004) were higher. In AN group we found: positive correlation between OC and BMI (r = 0.984, p = 0.0008), BF% (r = 0.983, p = 0,0008), Z score (r = 0.967, p = 0.0004), leptin (r = 0.985, p = 0.0001) and IGF-1 levels (r = 0.937, p = 0.0006); negative correlation between OC and cortisol (r = -0.982, p = 0.0005); negative correlation between PS-005 THE EFFECT OF BODY COMPOSITION CHANGES ON BONE MATABOLISM IN ADOLESCENTS WITH