Psychogenic non-epileptic seizures (PNES) is a conversion disorder that reflects underlying psychological distress. Female patients with PNES often present with a history of prolonged stressors, especially sexual abuse. In the current study, we studied the relationship between neuropeptide Y (NPY) and PNES symptoms in women with a history of sexual abuse. NPY has been associated with resilience to stress and we hypothesized that low levels would increase the extent and severity of PNES symptoms in this patient population. Serum levels of NPY, and related hormones were measured in fifteen female PNES patients and sixty female controls. PNES patients reported more severe abuse histories, feeling of abandonment, and decreased perception of quality of life than controls. Importantly, they also had lower NPY levels. Our analysis indicates that low levels of NPY in PNES may confer greater vulnerability to exhibit seizure-like symptoms and lower quality of life.

This paper introduces a new approach to economic analysis. We show how to move from deductive to inductive modeling and thereby reunite economics with approaches used in the natural sciences. This paper presents the empathy-generosity-punishment model as an example of research based on observation, experimentation, and the elimination of alternatives. Inductive modeling in neuroeconomics allows the identification of the physiologic mechanisms that produce behavior. Unlike most neuroeconomics studies, we show how to establish causation by using drugs to manipulate brain activity. This approach is demonstrated using three experiments that circumscribe the brain processes behind prosocial behavior.oxytocin, testosterone, social preferences, modeling, induction,

Although many of us interact daily with animals, we have little understanding of how this affects our interactions with people. This study assessed the physiological effects of human-animal interactions and tested if this affected interpersonaltrust. Participants (N=141) were assigned to play with a friendly but unfamiliar cat or dog for 10 minutes or to rest quietly in a private room. Blood was obtained from human participants before and after animal interactions or rest, and videos of animal interactions were coded for encounter styles. Participants then made interpersonal monetary decisions to quantify trust and trustworthiness toward strangers. Although oxytocin (OT) fell on average after interactions with both dogs and cats, there was a positive and significant correlation between the change in OT after interacting with a dog and lifetime pet exposure. Participants who had lived with four or more dogs in their lifetimes had a positive increase in OT after interacting with an unknown dog. We found a negative correlation between the change in OT after interacting with a cat and cat ownership. Participants who had a reduction in stress hormones after a dog interaction showed increased trust in strangers. Specifically, a one-percentage-point decrease in the stress hormone adrenocorticotropin hormone increased trust in a stranger by 24 percent. Our findings show that the human OT response to animals depends on previous pet exposure.

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